Multifunctional gold nanostar-based nanocomposite: Synthesis and application for noninvasive MR-SERS imaging-guided photothermal ablation

Abstract We report here the design and facile synthesis of multifunctional gold nanostars based nanocomposites (MGSNs) through direct organosilica coating onto anisotropic gold nanostars followed by the conjugation of Gd chelates. The as-synthesized MGSNs possess strong NIR absorbance, SERS signal a...

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Bibliographic Details
Published in:Biomaterials 2015-08, Vol.60, p.31-41
Main Authors: Gao, Yongping, Li, Yongsheng, Chen, Jianzhuang, Zhu, Shaojia, Liu, Xiaohang, Zhou, Liangping, Shi, Ping, Niu, Dechao, Gu, Jinlou, Shi, Jianlin
Format: Article
Language:English
Subjects:
Ablation
Advanced Basic Science
Animals
Biomedical materials
Cell Line, Tumor
Chelating Agents - chemistry
Chelating Agents - therapeutic use
Dentistry
Gold
Gold - chemistry
Gold - therapeutic use
Heterocyclic Compounds - chemistry
Heterocyclic Compounds - therapeutic use
Humans
Imaging
Magnetic Resonance Imaging - methods
Mice, Inbred BALB C
MRI
Nanocomposite
Nanocomposites - chemistry
Nanocomposites - therapeutic use
Nanocomposites - ultrastructure
Nanostructure
Neoplasms - pathology
Neoplasms - therapy
Organometallic Compounds - chemistry
Organometallic Compounds - therapeutic use
Organosilicon Compounds - chemistry
Organosilicon Compounds - therapeutic use
Phototherapy - methods
Photothermal therapy
Polyethylene Glycols - chemistry
Polyethylene Glycols - therapeutic use
SERS
Spectrum Analysis, Raman - methods
Surgical implants
Synthesis
Tumors
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Summary:Abstract We report here the design and facile synthesis of multifunctional gold nanostars based nanocomposites (MGSNs) through direct organosilica coating onto anisotropic gold nanostars followed by the conjugation of Gd chelates. The as-synthesized MGSNs possess strong NIR absorbance, SERS signal and enhanced T1 -MR imaging capability with excellent dispersivity and uniform size, as well as great photothermal stability and Raman stability under photothermal conditions. Importantly, MGSNs present excellent performance in vivo after their intravenous injection for both MR and SERS imaging and the high efficiency for killing tumor cells through photothermal ablation with NIR irradiation. A combination of the high spatial resolution of MR and the exciting sub-cell-level sensitivity and resolution of SERS can provide comprehensive information about the tumor to achieve the optimized therapeutic outcome. Therefore, MGSNs are of great potential as a multifunctional nanoplatform for MR-SERS bimodal imaging-guided, focused photothermal tumor therapy.
ISSN:0142-9612
1878-5905
DOI:10.1016/j.biomaterials.2015.05.004