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Multifunctional gold nanostar-based nanocomposite: Synthesis and application for noninvasive MR-SERS imaging-guided photothermal ablation
Abstract We report here the design and facile synthesis of multifunctional gold nanostars based nanocomposites (MGSNs) through direct organosilica coating onto anisotropic gold nanostars followed by the conjugation of Gd chelates. The as-synthesized MGSNs possess strong NIR absorbance, SERS signal a...
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| Published in: | Biomaterials 2015-08, Vol.60, p.31-41 |
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| Main Authors: | , , , , , , , , , |
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| cited_by | cdi_FETCH-LOGICAL-c567t-af682ef38966c7081a6abc687308d726935ccfb7cdbc2448bc4a77b618c115e33 |
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| cites | cdi_FETCH-LOGICAL-c567t-af682ef38966c7081a6abc687308d726935ccfb7cdbc2448bc4a77b618c115e33 |
| container_end_page | 41 |
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| container_start_page | 31 |
| container_title | Biomaterials |
| container_volume | 60 |
| creator | Gao, Yongping Li, Yongsheng Chen, Jianzhuang Zhu, Shaojia Liu, Xiaohang Zhou, Liangping Shi, Ping Niu, Dechao Gu, Jinlou Shi, Jianlin |
| description | Abstract We report here the design and facile synthesis of multifunctional gold nanostars based nanocomposites (MGSNs) through direct organosilica coating onto anisotropic gold nanostars followed by the conjugation of Gd chelates. The as-synthesized MGSNs possess strong NIR absorbance, SERS signal and enhanced T1 -MR imaging capability with excellent dispersivity and uniform size, as well as great photothermal stability and Raman stability under photothermal conditions. Importantly, MGSNs present excellent performance in vivo after their intravenous injection for both MR and SERS imaging and the high efficiency for killing tumor cells through photothermal ablation with NIR irradiation. A combination of the high spatial resolution of MR and the exciting sub-cell-level sensitivity and resolution of SERS can provide comprehensive information about the tumor to achieve the optimized therapeutic outcome. Therefore, MGSNs are of great potential as a multifunctional nanoplatform for MR-SERS bimodal imaging-guided, focused photothermal tumor therapy. |
| doi_str_mv | 10.1016/j.biomaterials.2015.05.004 |
| format | article |
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The as-synthesized MGSNs possess strong NIR absorbance, SERS signal and enhanced T1 -MR imaging capability with excellent dispersivity and uniform size, as well as great photothermal stability and Raman stability under photothermal conditions. Importantly, MGSNs present excellent performance in vivo after their intravenous injection for both MR and SERS imaging and the high efficiency for killing tumor cells through photothermal ablation with NIR irradiation. A combination of the high spatial resolution of MR and the exciting sub-cell-level sensitivity and resolution of SERS can provide comprehensive information about the tumor to achieve the optimized therapeutic outcome. Therefore, MGSNs are of great potential as a multifunctional nanoplatform for MR-SERS bimodal imaging-guided, focused photothermal tumor therapy.</description><identifier>ISSN: 0142-9612</identifier><identifier>EISSN: 1878-5905</identifier><identifier>DOI: 10.1016/j.biomaterials.2015.05.004</identifier><identifier>PMID: 25982551</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Ablation ; Advanced Basic Science ; Animals ; Biomedical materials ; Cell Line, Tumor ; Chelating Agents - chemistry ; Chelating Agents - therapeutic use ; Dentistry ; Gold ; Gold - chemistry ; Gold - therapeutic use ; Heterocyclic Compounds - chemistry ; Heterocyclic Compounds - therapeutic use ; Humans ; Imaging ; Magnetic Resonance Imaging - methods ; Mice, Inbred BALB C ; MRI ; Nanocomposite ; Nanocomposites - chemistry ; Nanocomposites - therapeutic use ; Nanocomposites - ultrastructure ; Nanostructure ; Neoplasms - pathology ; Neoplasms - therapy ; Organometallic Compounds - chemistry ; Organometallic Compounds - therapeutic use ; Organosilicon Compounds - chemistry ; Organosilicon Compounds - therapeutic use ; Phototherapy - methods ; Photothermal therapy ; Polyethylene Glycols - chemistry ; Polyethylene Glycols - therapeutic use ; SERS ; Spectrum Analysis, Raman - methods ; Surgical implants ; Synthesis ; Tumors</subject><ispartof>Biomaterials, 2015-08, Vol.60, p.31-41</ispartof><rights>Elsevier Ltd</rights><rights>2015 Elsevier Ltd</rights><rights>Copyright © 2015 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c567t-af682ef38966c7081a6abc687308d726935ccfb7cdbc2448bc4a77b618c115e33</citedby><cites>FETCH-LOGICAL-c567t-af682ef38966c7081a6abc687308d726935ccfb7cdbc2448bc4a77b618c115e33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25982551$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gao, Yongping</creatorcontrib><creatorcontrib>Li, Yongsheng</creatorcontrib><creatorcontrib>Chen, Jianzhuang</creatorcontrib><creatorcontrib>Zhu, Shaojia</creatorcontrib><creatorcontrib>Liu, Xiaohang</creatorcontrib><creatorcontrib>Zhou, Liangping</creatorcontrib><creatorcontrib>Shi, Ping</creatorcontrib><creatorcontrib>Niu, Dechao</creatorcontrib><creatorcontrib>Gu, Jinlou</creatorcontrib><creatorcontrib>Shi, Jianlin</creatorcontrib><title>Multifunctional gold nanostar-based nanocomposite: Synthesis and application for noninvasive MR-SERS imaging-guided photothermal ablation</title><title>Biomaterials</title><addtitle>Biomaterials</addtitle><description>Abstract We report here the design and facile synthesis of multifunctional gold nanostars based nanocomposites (MGSNs) through direct organosilica coating onto anisotropic gold nanostars followed by the conjugation of Gd chelates. The as-synthesized MGSNs possess strong NIR absorbance, SERS signal and enhanced T1 -MR imaging capability with excellent dispersivity and uniform size, as well as great photothermal stability and Raman stability under photothermal conditions. Importantly, MGSNs present excellent performance in vivo after their intravenous injection for both MR and SERS imaging and the high efficiency for killing tumor cells through photothermal ablation with NIR irradiation. A combination of the high spatial resolution of MR and the exciting sub-cell-level sensitivity and resolution of SERS can provide comprehensive information about the tumor to achieve the optimized therapeutic outcome. Therefore, MGSNs are of great potential as a multifunctional nanoplatform for MR-SERS bimodal imaging-guided, focused photothermal tumor therapy.</description><subject>Ablation</subject><subject>Advanced Basic Science</subject><subject>Animals</subject><subject>Biomedical materials</subject><subject>Cell Line, Tumor</subject><subject>Chelating Agents - chemistry</subject><subject>Chelating Agents - therapeutic use</subject><subject>Dentistry</subject><subject>Gold</subject><subject>Gold - chemistry</subject><subject>Gold - therapeutic use</subject><subject>Heterocyclic Compounds - chemistry</subject><subject>Heterocyclic Compounds - therapeutic use</subject><subject>Humans</subject><subject>Imaging</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Mice, Inbred BALB C</subject><subject>MRI</subject><subject>Nanocomposite</subject><subject>Nanocomposites - chemistry</subject><subject>Nanocomposites - therapeutic use</subject><subject>Nanocomposites - ultrastructure</subject><subject>Nanostructure</subject><subject>Neoplasms - pathology</subject><subject>Neoplasms - therapy</subject><subject>Organometallic Compounds - chemistry</subject><subject>Organometallic Compounds - therapeutic use</subject><subject>Organosilicon Compounds - chemistry</subject><subject>Organosilicon Compounds - therapeutic use</subject><subject>Phototherapy - methods</subject><subject>Photothermal therapy</subject><subject>Polyethylene Glycols - chemistry</subject><subject>Polyethylene Glycols - therapeutic use</subject><subject>SERS</subject><subject>Spectrum Analysis, Raman - methods</subject><subject>Surgical implants</subject><subject>Synthesis</subject><subject>Tumors</subject><issn>0142-9612</issn><issn>1878-5905</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNqNUt1qFDEUDqLYtfoKMnjlzaw5mcnP9EKQtrZCi9DV65DJZLZZM8mYzCzsI_jWZtwq4o2FA4cD3w_nfAehN4DXgIG9261bGwY1mWiVS2uCga5xLlw_QSsQXJS0wfQpWmGoSdkwICfoRUo7nGdck-fohNBGEEphhX7czm6y_ez1ZINXrtgG1xVe-ZAmFctWJXMcdRjGkOxkzorNwU_3JtlUKN8Vahyd1WqhF32IhQ_e-r1Kdm-K27tyc3m3KeygttZvy-1su6w33ocpZIk4ZEPVul_kl-hZn9cxrx76Kfr68fLL-XV58_nq0_mHm1JTxqdS9UwQ01eiYUxzLEAx1WomeIVFxwlrKqp133LdtZrUtWh1rThvGQgNQE1VnaK3R90xhu-zSZMcbNLGOeVNmJMEznFVZSV4BLSiDVDA-P9QJlhNADjN0LMjVMeQUjS9HGM-UDxIwHIJWO7k3wHLJWCJc-E6k18_-MztYLo_1N-JZsDFEWDyDffWRJm0NV6bzkajJ9kF-zif9__IaGd9ztl9MweTdmGOfuGATERiuVlebfk0oJlN8pY_ATQ71TQ</recordid><startdate>20150801</startdate><enddate>20150801</enddate><creator>Gao, Yongping</creator><creator>Li, Yongsheng</creator><creator>Chen, Jianzhuang</creator><creator>Zhu, Shaojia</creator><creator>Liu, Xiaohang</creator><creator>Zhou, Liangping</creator><creator>Shi, Ping</creator><creator>Niu, Dechao</creator><creator>Gu, Jinlou</creator><creator>Shi, Jianlin</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7SR</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>F28</scope><scope>JG9</scope><scope>L7M</scope></search><sort><creationdate>20150801</creationdate><title>Multifunctional gold nanostar-based nanocomposite: Synthesis and application for noninvasive MR-SERS imaging-guided photothermal ablation</title><author>Gao, Yongping ; Li, Yongsheng ; Chen, Jianzhuang ; Zhu, Shaojia ; Liu, Xiaohang ; Zhou, Liangping ; Shi, Ping ; Niu, Dechao ; Gu, Jinlou ; Shi, Jianlin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c567t-af682ef38966c7081a6abc687308d726935ccfb7cdbc2448bc4a77b618c115e33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Ablation</topic><topic>Advanced Basic Science</topic><topic>Animals</topic><topic>Biomedical materials</topic><topic>Cell Line, Tumor</topic><topic>Chelating Agents - chemistry</topic><topic>Chelating Agents - therapeutic use</topic><topic>Dentistry</topic><topic>Gold</topic><topic>Gold - chemistry</topic><topic>Gold - therapeutic use</topic><topic>Heterocyclic Compounds - chemistry</topic><topic>Heterocyclic Compounds - therapeutic use</topic><topic>Humans</topic><topic>Imaging</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Mice, Inbred BALB C</topic><topic>MRI</topic><topic>Nanocomposite</topic><topic>Nanocomposites - chemistry</topic><topic>Nanocomposites - therapeutic use</topic><topic>Nanocomposites - ultrastructure</topic><topic>Nanostructure</topic><topic>Neoplasms - pathology</topic><topic>Neoplasms - therapy</topic><topic>Organometallic Compounds - chemistry</topic><topic>Organometallic Compounds - therapeutic use</topic><topic>Organosilicon Compounds - chemistry</topic><topic>Organosilicon Compounds - therapeutic use</topic><topic>Phototherapy - methods</topic><topic>Photothermal therapy</topic><topic>Polyethylene Glycols - chemistry</topic><topic>Polyethylene Glycols - therapeutic use</topic><topic>SERS</topic><topic>Spectrum Analysis, Raman - methods</topic><topic>Surgical implants</topic><topic>Synthesis</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gao, Yongping</creatorcontrib><creatorcontrib>Li, Yongsheng</creatorcontrib><creatorcontrib>Chen, Jianzhuang</creatorcontrib><creatorcontrib>Zhu, Shaojia</creatorcontrib><creatorcontrib>Liu, Xiaohang</creatorcontrib><creatorcontrib>Zhou, Liangping</creatorcontrib><creatorcontrib>Shi, Ping</creatorcontrib><creatorcontrib>Niu, Dechao</creatorcontrib><creatorcontrib>Gu, Jinlou</creatorcontrib><creatorcontrib>Shi, Jianlin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Biomaterials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gao, Yongping</au><au>Li, Yongsheng</au><au>Chen, Jianzhuang</au><au>Zhu, Shaojia</au><au>Liu, Xiaohang</au><au>Zhou, Liangping</au><au>Shi, Ping</au><au>Niu, Dechao</au><au>Gu, Jinlou</au><au>Shi, Jianlin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Multifunctional gold nanostar-based nanocomposite: Synthesis and application for noninvasive MR-SERS imaging-guided photothermal ablation</atitle><jtitle>Biomaterials</jtitle><addtitle>Biomaterials</addtitle><date>2015-08-01</date><risdate>2015</risdate><volume>60</volume><spage>31</spage><epage>41</epage><pages>31-41</pages><issn>0142-9612</issn><eissn>1878-5905</eissn><abstract>Abstract We report here the design and facile synthesis of multifunctional gold nanostars based nanocomposites (MGSNs) through direct organosilica coating onto anisotropic gold nanostars followed by the conjugation of Gd chelates. The as-synthesized MGSNs possess strong NIR absorbance, SERS signal and enhanced T1 -MR imaging capability with excellent dispersivity and uniform size, as well as great photothermal stability and Raman stability under photothermal conditions. Importantly, MGSNs present excellent performance in vivo after their intravenous injection for both MR and SERS imaging and the high efficiency for killing tumor cells through photothermal ablation with NIR irradiation. A combination of the high spatial resolution of MR and the exciting sub-cell-level sensitivity and resolution of SERS can provide comprehensive information about the tumor to achieve the optimized therapeutic outcome. Therefore, MGSNs are of great potential as a multifunctional nanoplatform for MR-SERS bimodal imaging-guided, focused photothermal tumor therapy.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>25982551</pmid><doi>10.1016/j.biomaterials.2015.05.004</doi><tpages>11</tpages></addata></record> |
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| subjects | Ablation Advanced Basic Science Animals Biomedical materials Cell Line, Tumor Chelating Agents - chemistry Chelating Agents - therapeutic use Dentistry Gold Gold - chemistry Gold - therapeutic use Heterocyclic Compounds - chemistry Heterocyclic Compounds - therapeutic use Humans Imaging Magnetic Resonance Imaging - methods Mice, Inbred BALB C MRI Nanocomposite Nanocomposites - chemistry Nanocomposites - therapeutic use Nanocomposites - ultrastructure Nanostructure Neoplasms - pathology Neoplasms - therapy Organometallic Compounds - chemistry Organometallic Compounds - therapeutic use Organosilicon Compounds - chemistry Organosilicon Compounds - therapeutic use Phototherapy - methods Photothermal therapy Polyethylene Glycols - chemistry Polyethylene Glycols - therapeutic use SERS Spectrum Analysis, Raman - methods Surgical implants Synthesis Tumors |
| title | Multifunctional gold nanostar-based nanocomposite: Synthesis and application for noninvasive MR-SERS imaging-guided photothermal ablation |
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