Mesoporous silica nanoparticles with manipulated microstructures for drug delivery

• Published in: Colloids and surfaces, B, Biointerfaces B, Biointerfaces, 2012-06, Vol.95, p.274-278
• Main Authors: Chen, Zhongdong, Li, Xiang, He, Haiyan, Ren, Zhaohui, Liu, Yong, Wang, Juan, Li, Zhe, Shen, Ge, Han, Gaorong
• Format: Article
• Language: English
• Subjects: colloids; composite polymers; Controlled mesoporous structure; Curvature; Drug Delivery Systems; Drug releasing kinetics; Drugs; ibuprofen; Ibuprofen - chemistry; Ibuprofen - metabolism; Kinetics; Microstructure; Molecular Structure; Nanoparticles; Nanoparticles - chemistry; Particle Size; Poloxamer - chemical synthesis; Poloxamer - chemistry; Porosity; Releasing; silica; Silica nanoparticle; Silicon dioxide; Silicon Dioxide - chemical synthesis; Silicon Dioxide - chemistry; surface area; Surface Properties; Surface-Active Agents - chemical synthesis; Surface-Active Agents - chemistry; Surfactants
• ISSN: 0927-7765; 1873-4367
• DOI: 10.1016/j.colsurfb.2012.03.012

[Display omitted] ► The as-prepared MSNs with manipulated morphology and structural characteristics by varying F127 concentration. ► The pore length and curvature was changed with the shape of MSNs. ► The drug-loading amount was determined by specific surface areas. ► The length and curvature of the mesopores impact on the drug releasing characteristics. A range of mesoporous silica nanoparticles (MSNs) with controlled microstructural characteristics were successfully prepared via the binary surfactant templated synthesis approach with varied concentration of triblock copolymer Pluronic F127. The relationship between the MSNs structural evolution and the surfactant concentration was extensively discussed. Ibuprofen (IBU) was loaded as drug model to uncover the in vitro drug releasing kinetics. It was found that the quantity of the drug loaded mainly depended on the specific surface area, while the drug releasing rate was dominantly determined by the length and curvature of the mesopores. This study has uncovered the core influential factors of MSNs system on its drug releasing properties, and thus demonstrated a facile approach to prepare MSNs with manipulated structural characteristics for drug delivery applications.