Cytochrome P-450 2C9 Sensitizes Human Prostate Tumor Cells to Cyclophosphamide via a Bystander Effect

• Published in: Antimicrobial Agents and Chemotherapy 2000-10, Vol.44 (10), p.2659-2663
• Main Authors: Zhou, D, Lu, Y, Steiner, M S, Dalton, J T
• Format: Article
• Language: English
• Subjects: Antineoplastic agents; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Alkylating - metabolism; Antineoplastic Agents, Alkylating - pharmacology; Aryl Hydrocarbon Hydroxylases; Biological and medical sciences; Biotransformation; Blotting, Western; Cell Survival - drug effects; Cyclophosphamide; Cyclophosphamide - metabolism; Cyclophosphamide - pharmacology; Cytochrome P-450 CYP2C9; Cytochrome P-450 Enzyme System; Cytochrome P-450 Enzyme System - genetics; Cytochrome P-450 Enzyme System - metabolism; Cytochrome P-450 Enzyme System - pharmacology; diclofenac; Diclofenac - analogs & derivatives; Diclofenac - metabolism; General aspects; Humans; Kinetics; lymphoblastoid cells; Male; Mechanisms of Action: Physiological Effects; Medical sciences; Pharmacology. Drug treatments; Prodrugs; Prostatic Neoplasms; Prostatic Neoplasms - drug therapy; Prostatic Neoplasms - enzymology; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Steroid Hydroxylases - genetics; Steroid Hydroxylases - metabolism; Steroid Hydroxylases - pharmacology; Tumor Cells, Cultured
• ISSN: 0066-4804; 1098-6596
• DOI: 10.1128/aac.44.10.2659-2663.2000

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