Interferon induced Autoimmune Thyroid Disease (AITD): a model for human autoimmunity

Interferon (IFN) α treatment for various conditions has been associated with thyroid autoimmunity. The incidence of interferon induced thyroid autoimmunity has been reported to range from 2.5% to 42%, possibly depending upon dose and duration of medical therapy and patient characteristics. It is not...

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Bibliographic Details
Published in:Autoimmunity reviews 2004-07, Vol.3 (5), p.388-393
Main Authors: Oppenheim, Yael, Ban, Yoshiyuki, Tomer, Yaron
Format: Article
Language:English
Subjects:
Animals
Antiviral Agents - adverse effects
Disease Models, Animal
Hepatitis C
Humans
Interferon-α
Interferons - adverse effects
Risk Factors
Thyroid autoantibody
Thyroid autoimmunity
Thyroiditis, Autoimmune - chemically induced
Thyroiditis, Autoimmune - immunology
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Summary:Interferon (IFN) α treatment for various conditions has been associated with thyroid autoimmunity. The incidence of interferon induced thyroid autoimmunity has been reported to range from 2.5% to 42%, possibly depending upon dose and duration of medical therapy and patient characteristics. It is not known whether IFN-α initiates autoimmune thyroid disease (AITD) or simply exacerbates AITD in individuals with subclinical AITD.
ISSN:1568-9972
1568-9972
DOI:10.1016/j.autrev.2004.03.003