Endocrine Therapy in Breast Cancer: The Neoadjuvant, Adjuvant, and Metastatic Approach

To review the rationale for endocrine therapy in the neoadjuvant, adjuvant, and metastatic breast cancer setting and to highlight clinical considerations unique to this treatment. Contemporary literature, clinical guidelines, and national statistics. Endocrine therapy represents an important strateg...

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Bibliographic Details
Published in:Seminars in oncology nursing 2015-05, Vol.31 (2), p.146-155
Main Authors: Reinbolt, Raquel E., Mangini, Neha, Hill, Jordan L., Levine, Lauren B., Dempsey, Jessica L., Singaravelu, Janani, Koehler, Kevin A., Talley, Allison, Lustberg, Maryam B.
Format: Article
Language:English
Subjects:
Antineoplastic Agents, Hormonal - therapeutic use
aromatase inhibitors
Aromatase Inhibitors - therapeutic use
breast cancer
Breast Neoplasms - drug therapy
Breast Neoplasms - nursing
Chemotherapy, Adjuvant - nursing
Endocrine System - drug effects
Endocrine therapy
Female
Humans
Neoplasm Metastasis - drug therapy
Nursing
Oncology Nursing - methods
tamoxifen
Tamoxifen - therapeutic use
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Summary:To review the rationale for endocrine therapy in the neoadjuvant, adjuvant, and metastatic breast cancer setting and to highlight clinical considerations unique to this treatment. Contemporary literature, clinical guidelines, and national statistics. Endocrine therapy represents an important strategy in the management of both early and advanced hormone positive breast cancer. Additional research is required to better define the role of neoadjuvant therapy and the optimal duration of treatment. Nurses play a pivotal role in the identification and management of endocrine therapy-associated symptoms. Prompt symptom intervention may improve therapy adherence and ultimately, may improve long-term disease outcomes.
ISSN:0749-2081
1878-3449
DOI:10.1016/j.soncn.2015.02.002