Impact of a personal CYP2D6 testing workshop on physician assistant student attitudes toward pharmacogenetics

We assessed the impact of personal CYP2D6 testing on physician assistant student competency in, and attitudes toward, pharmacogenetics (PGx). Buccal samples were genotyped for CYP2D6 polymorphisms. Results were discussed during a 3-h PGx workshop. PGx knowledge was assessed by pre- and post-tests. F...

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Bibliographic Details
Published in:Pharmacogenomics 2016-03, Vol.17 (4), p.341-352
Main Authors: O'Brien, Travis J, LeLacheur, Susan, Ward, Caitlin, Lee, Norman H, Callier, Shawneequa, Harralson, Arthur F
Format: Article
Language:English
Subjects:
Attitudes
Biomarkers
Clinical Competence
Clinical medicine
Curricula
CYP2D6 protein
Cytochrome
Cytochrome P-450 CYP2D6 - genetics
Cytochrome P450
Drug stores
Education
Genetic counseling
Genetic Testing
Genetics
Genomes
Genomics
Humans
Laboratories
Learning
Pharmacists
Pharmacogenetics
Pharmacogenetics - education
Physician Assistants - education
Polymorphism
Precision medicine
Professions
Students
Teaching - methods
Transfer learning
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Summary:We assessed the impact of personal CYP2D6 testing on physician assistant student competency in, and attitudes toward, pharmacogenetics (PGx). Buccal samples were genotyped for CYP2D6 polymorphisms. Results were discussed during a 3-h PGx workshop. PGx knowledge was assessed by pre- and post-tests. Focus groups assessed the impact of the workshop on attitudes toward the clinical utility of PGx. Both student knowledge of PGx, and its perceived clinical utility, increased immediately following the workshop. However, exposure to PGx on clinical rotations following the workshop seemed to influence student attitudes toward PGx utility. Personal CYP2D6 testing improves both knowledge and comfort with PGx. Continued exposure to PGx concepts is important for transfer of learning.
ISSN:1462-2416
1744-8042
DOI:10.2217/pgs.15.182