Can immediate postoperative random growth hormone levels predict long-term cure in patients with acromegaly?

Background: Growth hormone (GH) levels following oral glucose tolerance test (OGTT) at 12 weeks or later after surgery have been accepted as the most reliable parameter for defining remission and/or cure in patients with acromegaly. However, the role of random GH in predicting remission in the immed...

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Bibliographic Details
Published in:Neurology India 2016-03, Vol.64 (2), p.252-258
Main Authors: Dutta, Pinaki, Korbonits, Márta, Sachdeva, Naresh, Gupta, Prakamya, Srinivasan, Anand, Devgun, Jagtar, Bajaj, Ankur, Mukherjee, Kanchan
Format: Article
Language:English
Subjects:
Acromegaly
Acromegaly - surgery
Analysis
Conflicts of interest
Glucose Tolerance Test
Growth hormones
Hospitals
Human Growth Hormone - analysis
Humans
Insulin-Like Growth Factor I - analysis
Insulin-like growth factors
NMR
Nuclear magnetic resonance
Pituitary gland
Postoperative Period
Predictive Value of Tests
Prognosis
Radiation therapy
Sensitivity and Specificity
Statistical analysis
Surgery
Treatment Outcome
Tumors
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Summary:Background: Growth hormone (GH) levels following oral glucose tolerance test (OGTT) at 12 weeks or later after surgery have been accepted as the most reliable parameter for defining remission and/or cure in patients with acromegaly. However, the role of random GH in predicting remission in the immediate postoperative period using modern criteria is not known. This study was undertaken to evaluate the role of random GH levels in first 5 postoperative days as an early predictive tool for long-term remission of patients with acromegaly following transsphenoidal pituitary surgery (TSS). Patients and Methods: Seventy-five consecutive acromegaly patients with at least three postoperative OGTT values at 3, 6, and 12 months of follow-up were included in the study. GH levels were measured just before surgery, in the immediate postoperative period, at 6 h and on day 1 to day 5 after surgery. Remission was defined as normal age-specific insulin-like growth factor-1 and either basal fasting GH
ISSN:0028-3886
1998-4022
DOI:10.4103/0028-3886.177622