Gene expression profiles in normal and Otx2 super(-/-) early gastrulating mouse embryos

The mouse Otx2 gene is a homeobox transcription factor required as early as gastrulation for the proper development of the head. We compared gene expression profiles in wild-type and Otx2 super(-/-) 6.5 days postcoitum embryos by using a serial analysis of gene expression assay adapted to microdisse...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 2000-12, Vol.97 (26), p.14388-14393
Main Authors: Zakin, L, Reversade, B, Virlon, B, Rusniok, C, Glaser, P, Elalouf, J, Brulet, P
Format: Article
Language:English
Subjects:
Otx2 gene
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Summary:The mouse Otx2 gene is a homeobox transcription factor required as early as gastrulation for the proper development of the head. We compared gene expression profiles in wild-type and Otx2 super(-/-) 6.5 days postcoitum embryos by using a serial analysis of gene expression assay adapted to microdissected structures. Among a broader list, the study of six genes found to be differentially expressed allows defining a role for Otx2 in the orchestration of cell movements leading to the adequate organization of the embryo before gastrulation.
ISSN:0027-8424