Incidence of Idiopathic Normal-Pressure Hydrocephalus in Northern Spain

Background Although the incidence of idiopathic normal-pressure hydrocephalus (iNPH) can be 1.20 cases/1000 inhabitants/year in individuals ≥70 years old, in most series, the incidence of shunt-responsive iNPH appears to be 60 years old and increased exponentially with age. After age 60, the standar...

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Bibliographic Details
Published in:World neurosurgery 2016-03, Vol.87, p.298-310
Main Authors: Martín-Láez, Rubén, Caballero-Arzapalo, Hugo, Valle-San Román, Natalia, López-Menéndez, Luis Ángel, Arango-Lasprilla, Juan Carlos, Vázquez-Barquero, Alfonso
Format: Article
Language:English
Subjects:
Adult
Age Factors
Aged
Cerebrospinal Fluid Shunts
Cognitive Dysfunction - etiology
Epidemiology
Female
Humans
Hydrocephalus, Normal Pressure - complications
Hydrocephalus, Normal Pressure - diagnosis
Hydrocephalus, Normal Pressure - epidemiology
Hydrocephalus, Normal Pressure - physiopathology
Hydrocephalus, Normal Pressure - surgery
Idiopathic normal-pressure hydrocephalus
Incidence
Longitudinal Studies
Male
Middle Aged
Motor Disorders - etiology
Neurosurgery
Patient Selection
Prospective Studies
Sex Factors
Shunt-responsive hydrocephalus
Spain - epidemiology
Treatment Outcome
Ventriculomegaly
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Summary:Background Although the incidence of idiopathic normal-pressure hydrocephalus (iNPH) can be 1.20 cases/1000 inhabitants/year in individuals ≥70 years old, in most series, the incidence of shunt-responsive iNPH appears to be 60 years old and increased exponentially with age. After age 60, the standardized age- and sex-adjusted incidence rates for iNPH, shunt surgery for iNPH, and shunt-responsive iNPH were 13.36 cases/100,000 inhabitants/year, 10.85 cases/100,000 inhabitants/year, and 8.55 cases/100,000 inhabitants/year. No differences were detected in the response rate between probable and possible iNPH (80.52% vs. 76.00%; P  = 0.497). Conclusions Even with a protocol for patient referral in place, reported iNPH incidence was lower than predicted, reflecting a persistent problem of underdiagnosis in our population.
ISSN:1878-8750
1878-8769
DOI:10.1016/j.wneu.2015.10.069