Congenital Mesoblastic Nephroma Presenting With Hematuria in a Neonate: A Case Report

Congenital mesoblastic nephroma (CMN) is the most frequent renal neoplasm of newborns and young infants. Four cases presenting with hemorrhagic manifestations have been reported in the English literature (Hu et al, 2006; Bolande et al, 1967). We report the unusual clinical and radiographic findings...

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Bibliographic Details
Published in:Urology (Ridgewood, N.J.) N.J.), 2016-02, Vol.88, p.189-191
Main Authors: Kamaraj, Senthil, Arbuckle, Susan, Warner, Denise, Smith, Grahame, Karpelowsky, Jonathan
Format: Article
Language:English
Subjects:
Hematuria - etiology
Humans
Infant, Newborn
Kidney Neoplasms - complications
Kidney Neoplasms - congenital
Kidney Neoplasms - diagnosis
Male
Nephroma, Mesoblastic - complications
Nephroma, Mesoblastic - congenital
Nephroma, Mesoblastic - diagnosis
Urology
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Summary:Congenital mesoblastic nephroma (CMN) is the most frequent renal neoplasm of newborns and young infants. Four cases presenting with hemorrhagic manifestations have been reported in the English literature (Hu et al, 2006; Bolande et al, 1967). We report the unusual clinical and radiographic findings of a 2-day-old neonate with hematuria secondary to a CMN. The first ultrasound was equivocal. Repeat ultrasound followed by magnetic resonance imaging confirmed the diagnosis. He underwent a right nephroureterectomy with histopathology revealing a cellular variant of CMN without classical translocation (t12:15). Neonates presenting with hematuria require close follow-up and serial imaging to rule out occult renal tumors. Classical translocation may not be demonstrable in all the cases.
ISSN:0090-4295
1527-9995
DOI:10.1016/j.urology.2015.10.026