Ignorance is not bliss: Statistical power is not probability of trial success

The purpose of this commentary is to place probability of trial success, or assurance, in the context of decision making in drug development, and to illustrate its properties in an intuitive manner for the readers of Clinical Pharmacology and Therapeutics. The hope is that this will stimulate a dial...

Full description

Saved in:
Bibliographic Details
Published in:Clinical pharmacology and therapeutics 2016-04, Vol.99 (4), p.356-359
Main Authors: Zierhut, ML, Bycott, P, Gibbs, MA, Smith, BP, Vicini, P
Format: Article
Language:English
Subjects:
Animals
Bayes Theorem
Clinical Trials as Topic - statistics & numerical data
Data Interpretation, Statistical
Drug Discovery - statistics & numerical data
Humans
Models, Statistical
Probability
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The purpose of this commentary is to place probability of trial success, or assurance, in the context of decision making in drug development, and to illustrate its properties in an intuitive manner for the readers of Clinical Pharmacology and Therapeutics. The hope is that this will stimulate a dialog on how assurance should be incorporated into a quantitative decision approach for clinical development and trial design that uses all available information.
ISSN:0009-9236
1532-6535
DOI:10.1002/cpt.257