Maternal Cardiovascular Function in Normal Pregnancy: Evidence of Maladaptation to Chronic Volume Overload

The aim of this study was to investigate cardiac functional status in pregnancy using a comprehensive approach taking into account the simultaneous changes in loading and geometry, as well as maternal age and anthropometric indices. This was a prospective cross-sectional study of 559 nulliparous pre...

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Bibliographic Details
Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 2016-04, Vol.67 (4), p.754-762
Main Authors: Melchiorre, Karen, Sharma, Rajan, Khalil, Asma, Thilaganathan, Baskaran
Format: Article
Language:English
Subjects:
Adaptation, Physiological - physiology
Adult
Cardiac Output, High - diagnostic imaging
Cardiac Output, High - physiopathology
Cross-Sectional Studies
Echocardiography, Doppler - methods
Female
Gestational Age
Humans
Myocardial Contraction - physiology
Pregnancy - physiology
Prospective Studies
Reference Values
Risk Assessment
Statistics, Nonparametric
Stroke Volume - physiology
Ultrasonography, Prenatal - methods
United Kingdom
Vascular Resistance - physiology
Ventricular Function, Left - physiology
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Summary:The aim of this study was to investigate cardiac functional status in pregnancy using a comprehensive approach taking into account the simultaneous changes in loading and geometry, as well as maternal age and anthropometric indices. This was a prospective cross-sectional study of 559 nulliparous pregnant women assessed at 4 time points during pregnancy and at 1 year postpartum. All women underwent conventional echocardiography and tissue Doppler velocities and strain rate analysis at multiple cardiac sites. Mean arterial pressure and total vascular resistance index significantly decreased (both P
ISSN:0194-911X
1524-4563
DOI:10.1161/HYPERTENSIONAHA.115.06667