Cloning, Mapping, and Expression Analysis of a Gene Encoding a Novel Mammalian EGF-Related Protein (SCUBE1)

The epidermal growth factor (EGF) superfamily comprises a diverse group of proteins that function as secreted signaling molecules, growth factors, and components of the extracellular matrix, many with a role in vertebrate development. We have isolated a novel mammalian gene encoding an EGF-related p...

Full description

Saved in:
Bibliographic Details
Published in:Genomics (San Diego, Calif.) Calif.), 2000-11, Vol.70 (1), p.74-81
Main Authors: Grimmond, Sean, Larder, Rachel, Van Hateren, Nick, Siggers, Pam, Hulsebos, Theo J.M., Arkell, Ruth, Greenfield, Andy
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Astrocytoma - genetics
Biological and medical sciences
Calcium-Binding Proteins
chromosome 15
chromosome 22
Chromosome Mapping
Chromosomes, Human, Pair 22
Cloning, Molecular
Embryo, Mammalian
Epidermal Growth Factor - genetics
Epidermal Growth Factor - metabolism
epidermal growth factor-related protein
Fundamental and applied biological sciences. Psychology
Gene Expression
Genes. Genome
Humans
Intercellular Signaling Peptides and Proteins
Mice
Molecular and cellular biology
Molecular genetics
Molecular Sequence Data
Scube1 gene
Sequence Analysis, DNA
Sequence Homology, Amino Acid
Tissue Distribution
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The epidermal growth factor (EGF) superfamily comprises a diverse group of proteins that function as secreted signaling molecules, growth factors, and components of the extracellular matrix, many with a role in vertebrate development. We have isolated a novel mammalian gene encoding an EGF-related protein with a CUB (C1s-like) domain that defines a new mammalian gene family. The Scube1 (signal peptide-CUB domain-EGF-related 1) gene was isolated from a developing mouse urogenital ridge cDNA library and is expressed prominently in the developing gonad, nervous system, somites, surface ectoderm, and limb buds. We have mapped Scube1 to mouse chromosome 15 and show that it is orthologous to a human gene in the syntenic region of chromosome 22q13. We discuss the possible functions of this novel gene and its role in heritable disease in light of these data.
ISSN:0888-7543
1089-8646
DOI:10.1006/geno.2000.6370