Modulatory effects of methanol extract of Artocarpus altilis (Moraceae) on cadmium-induced hepatic and renal toxicity in male Wistar rats

Cadmium (Cd) is an environmental risk factor with an established toxicity in animals. Therefore, natural antioxidants may be protective against Cd-toxicity. The study was designed to investigate the modulatory effects of methanol extract of Artocarpus altilis (AA) on oxidant-antioxidant balance and...

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Bibliographic Details
Published in:Pathophysiology (Amsterdam) 2016-03, Vol.23 (1), p.1-9
Main Authors: Adaramoye, Oluwatosin Adekunle, Akanni, Olubukola Oyebimpe
Format: Article
Language:English
Subjects:
Antioxidant
Cadmium
Lipid profile
Quercetin
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Summary:Cadmium (Cd) is an environmental risk factor with an established toxicity in animals. Therefore, natural antioxidants may be protective against Cd-toxicity. The study was designed to investigate the modulatory effects of methanol extract of Artocarpus altilis (AA) on oxidant-antioxidant balance and lipid profile in liver and kidney of Cd-exposed rats while quercetin (QE) served as standard. Total phenolic content (TPC) and 2,2-diphenyl-1-picryldydrazyl (DPPH) radical scavenging activity of AA were assessed in vitro. In vivo, rats were orally treated with AA (200mg/kg) and QE (25mg/kg) daily for three weeks and challenged with two doses of Cd (1.5mg/kg, i.p.) in the last 72h. The TPC and DPPH scavenging effects of AA were high and comparable with catechin. Cd-intoxication significantly (p
ISSN:0928-4680
1873-149X
DOI:10.1016/j.pathophys.2015.07.003