Cholinergic circuitry functioning in patients with vascular cognitive impairment – no dementia

Highlights • This study first tested central cholinergic circuits by means of TMS in VCI–ND patients. • Unlike amnestic MCI, SAI of the motor cortex does not seem to be involved in VCI–ND. • SAI can be used as a probe of cholinergic pathways in different dementing processes. • SAI may help in identi...

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Bibliographic Details
Published in:Brain stimulation 2016-03, Vol.9 (2), p.225-233
Main Authors: Bella, Rita, Cantone, Mariagiovanna, Lanza, Giuseppe, Ferri, Raffaele, Vinciguerra, Luisa, Puglisi, Valentina, Pennisi, Manuela, Ricceri, Riccardo, Di Lazzaro, Vincenzo, Pennisi, Giovanni
Format: Article
Language:English
Subjects:
Acetylcholine
Aged
Alzheimer Disease - diagnosis
Alzheimer Disease - physiopathology
Case-Control Studies
Cholinergic Agents - therapeutic use
Cholinergic Neurons - physiology
Cognition
Cognitive Dysfunction - diagnosis
Cognitive Dysfunction - pathology
Cognitive Dysfunction - physiopathology
Cortical excitability
Dementia, Vascular - diagnosis
Diagnosis, Differential
Executive dysfunction
Female
Frontal Lobe - physiopathology
Humans
Male
Middle Aged
Motor Cortex - physiology
Neural Pathways
Neurology
Neuropsychological Tests
Synaptic Transmission
Transcranial Magnetic Stimulation
Vascular dementia
White Matter - pathology
White matter lesions
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Summary:Highlights • This study first tested central cholinergic circuits by means of TMS in VCI–ND patients. • Unlike amnestic MCI, SAI of the motor cortex does not seem to be involved in VCI–ND. • SAI can be used as a probe of cholinergic pathways in different dementing processes. • SAI may help in identifying responders to long-term treatment with cholinergic agents.
ISSN:1935-861X
1876-4754
DOI:10.1016/j.brs.2015.09.013