Carbapenem-resistant and colistin-resistant Escherichia coli co-producing NDM-9 and MCR-1

Given that colistin and carbapenem-resistant E coli can be found in retail meat, and that the resistance genes for crucial antimicrobials are located on conjugative plasmids, such strains might colonise the human intestinal tract and transfer the resistance plasmids to other Gram-negative pathogens,...

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Bibliographic Details
Published in:The Lancet infectious diseases 2016-03, Vol.16 (3), p.288-289
Main Authors: Yao, Xu, Doi, Yohei, Zeng, Li, Lv, Luchao, Liu, Jian-Hua
Format: Article
Language:English
Subjects:
Animals
Antimicrobial agents
Bacteriology
Colistin - therapeutic use
E coli
Enterobacteriaceae - drug effects
Enterobacteriaceae Infections - drug therapy
Enterobacteriaceae Infections - immunology
Genes
Humans
Infectious Disease
Infectious diseases
Plasmids
Plasmids - immunology
Polymyxins - therapeutic use
Swine Diseases - drug therapy
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Summary:Given that colistin and carbapenem-resistant E coli can be found in retail meat, and that the resistance genes for crucial antimicrobials are located on conjugative plasmids, such strains might colonise the human intestinal tract and transfer the resistance plasmids to other Gram-negative pathogens, which might result in untreatable infections. [...]the spread of mcr-1, especially into strains that are already resistant to carbapenems, must be stopped.
ISSN:1473-3099
1474-4457
DOI:10.1016/S1473-3099(16)00057-8