Rfp-Y genotype affects the fate of Rous sarcomas in B super(2) B super(5) chickens

Genes of the chicken major histocompatibility complex (Mhc), the B complex, are involved in the response to pathogens. The outcome of viral, bacterial, and parasitic insults is influenced by the particular Mhc genotype (as reviewed by Dietert et al. 1991; Kaufman et al. 1995, 1999). Unlike the mamma...

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Bibliographic Details
Published in:Immunogenetics (New York) 2000-07, Vol.51 (8/9), p.751-754
Main Authors: LePage, K T, Miller, M M, Elwood Briles, W, Taylor Jr, RL
Format: Article
Language:English
Subjects:
Marek's disease herpesvirus
Rfp-Y gene
Rous sarcoma virus
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Summary:Genes of the chicken major histocompatibility complex (Mhc), the B complex, are involved in the response to pathogens. The outcome of viral, bacterial, and parasitic insults is influenced by the particular Mhc genotype (as reviewed by Dietert et al. 1991; Kaufman et al. 1995, 1999). Unlike the mammalian multigene families of Mhc molecules, the chicken possesses only two class II beta and two class I alpha genes. A single locus in the B system is predominantly expressed for each of these classes (Kaufman et al. 1999; Zoorob et al. 1993). The peptide-binding specificity of the highly expressed class I locus and amount of this protein reaching the cell surface apparently determine the response to pathogens such as Rous sarcoma virus (RSV) and Marek's disease virus (MDV) (Kaufman et al. 1995, 1999).
ISSN:0093-7711