Evaluating the cytotoxicity of ionic liquids using human cell line HeLa

This paper presents cytotoxicity data of selected imidazolium ionic liquids evaluated in vitro on the human tumor cell line HeLa. It was found that for 1-n-butyl-3-methylimidazolium entities the toxicity depends strongly on the associated anion; EC50 values are lowest for tetrafluoroborate. No direc...

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Bibliographic Details
Published in:Human & experimental toxicology 2004-11, Vol.23 (11), p.513-517
Main Authors: Stepnowski, P, Skladanowski, A C, Ludwiczak, A, Laczyńska, E
Format: Article
Language:English
Subjects:
Biological and medical sciences
Borates - chemistry
Borates - toxicity
Cell Survival - drug effects
Chemical and industrial products toxicology. Toxic occupational diseases
Dose-Response Relationship, Drug
HeLa Cells - drug effects
HeLa Cells - pathology
Humans
Hydrophobic and Hydrophilic Interactions
Imidazoles - chemistry
Imidazoles - toxicity
Ions
Medical sciences
Quantitative Structure-Activity Relationship
Solvents
Solvents - toxicity
Toxicity Tests - methods
Toxicology
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Summary:This paper presents cytotoxicity data of selected imidazolium ionic liquids evaluated in vitro on the human tumor cell line HeLa. It was found that for 1-n-butyl-3-methylimidazolium entities the toxicity depends strongly on the associated anion; EC50 values are lowest for tetrafluoroborate. No direct dependence of the reduced effect concentration was found on elongating the short, methyl chain to ethyl or n-hexyl. Only for the ionic liquid with an n-decyl chain, the longest one studied, did higher hydrophobicity result in a EC50 one order of magnitude lower than that obtained with the n-butyl entity. The effect concentrations of imidazolium ionic liquids in the HeLa system used are lower than the values obtained for conventional organic solvents such as dichloromethane, toluene or xylene.
ISSN:0960-3271
1477-0903
DOI:10.1191/0960327104ht480oa