Expression of Cx36 in mammalian neurons

Cx36 is the first mammalian member of a novel subgroup of the connexin family, characterized by a long cytoplasmic loop, a peculiar gene structure and a preferential expression in cell types of neural origin. In the present review we summarize the evidence in favour of its predominant expression in...

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Bibliographic Details
Published in:Brain Research Reviews 2000-04, Vol.32 (1), p.72-85
Main Authors: Condorelli, Daniele F, Belluardo, Natale, Trovato-Salinaro, Angela, Mudò, Giuseppa
Format: Article
Language:English
Subjects:
Biological and medical sciences
connexin 36
Electrical synapses
Fundamental and applied biological sciences. Psychology
Gap junctions
Interneuronal communication
Isolated neuron and nerve. Neuroglia
Mammalia
Molecular neuroscience
Vertebrates: nervous system and sense organs
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Summary:Cx36 is the first mammalian member of a novel subgroup of the connexin family, characterized by a long cytoplasmic loop, a peculiar gene structure and a preferential expression in cell types of neural origin. In the present review we summarize the evidence in favour of its predominant expression in neuronal cells in the mammalian central nervous system, such as results from experiments with specific neurotoxins and co-localization of Cx36 mRNA and a neuronal marker. We also report a detailed description of Cx36 mRNA distribution in the rat and human central nervous system by in situ hybridization and, for each brain region, we correlate the novel findings with previous morphological or functional demonstrations of neuronal gap junctions in the same area.
ISSN:0165-0173
1872-6321
DOI:10.1016/S0165-0173(99)00068-5