The effects of centrally injected arachidonic acid on respiratory system; Involvement of cyclooxygenase to thromboxane signaling pathway

Highlights • AA clearly exerts hyperventilation effect. • AA increases pO2 and decreases pCO2. • The blockade of cyclooxygenase enzymes activity greatly abolishes the respiratory effects of AA • The inhibition of thromboxane synthesis substantially attenuates AA evoked respiratory responses.

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Bibliographic Details
Published in:Respiratory physiology & neurobiology 2016-05, Vol.225, p.1-7
Main Authors: Erkan, Leman Gizem, Guvenc, Gokcen, Altinbas, Burcin, Niaz, Nasir, Yalcin, Murat
Format: Article
Language:English
Subjects:
Anesthesia
Animals
Arachidonic acid
Arachidonic Acid - pharmacology
Benzofurans - pharmacology
Carbon Dioxide - blood
Cyclooxygenase
Dose-Response Relationship, Drug
Enzyme Inhibitors - pharmacology
Ibuprofen - pharmacology
Injections, Intraventricular
Intracerebroventricular
Male
Medical Education
Oxygen - blood
Partial carbon dioxide pressure
Partial oxygen pressure
Prostaglandin-Endoperoxide Synthases - metabolism
Pulmonary/Respiratory
Rats, Sprague-Dawley
Respiration - drug effects
Respiratory Minute Ventilation
Respiratory rate
Respiratory System - drug effects
Respiratory System - enzymology
Respiratory System Agents - pharmacology
Thromboxane A2
Thromboxane A2 - metabolism
Tidal volume
Tidal Volume - drug effects
Tidal Volume - physiology
Time Factors
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Description
Summary:Highlights • AA clearly exerts hyperventilation effect. • AA increases pO2 and decreases pCO2. • The blockade of cyclooxygenase enzymes activity greatly abolishes the respiratory effects of AA • The inhibition of thromboxane synthesis substantially attenuates AA evoked respiratory responses.
ISSN:1569-9048
1878-1519
DOI:10.1016/j.resp.2015.12.010