Upregulation of the double-stranded RNA binding protein DGCR8 in invasive ductal breast carcinoma

High-throughput experimental studies have indicated that the miRNAome is globally downregulated in various types of malignancy, and dysregulation of miRNAs processing component(s) is one possible mechanism for this phenomenon. Despite the progression in identifying cellular functions of Digeorge Syn...

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Bibliographic Details
Published in:Gene 2016-05, Vol.581 (2), p.146-151
Main Authors: Fardmanesh, Hedieh, Shekari, Mohammad, Movafagh, Abolfazl, Alizadeh Shargh, Shohreh, Poursadegh Zonouzi, Ali Akbar, Shakerizadeh, Samira, Poursadegh Zonouzi, Ahmad, Hosseinzadeh, Asghar
Format: Article
Language:English
Subjects:
Adult
Aged
Breast Neoplasms - genetics
Breast Neoplasms - pathology
Carcinoma, Ductal, Breast - genetics
Carcinoma, Ductal, Breast - pathology
DGCR8
Female
Gene Expression Regulation, Neoplastic
Genetic Predisposition to Disease
Humans
Invasive Ductal Breast carcinoma
MicroRNA
MicroRNA processing pathway
Middle Aged
RNA-Binding Proteins - genetics
Up-Regulation
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Summary:High-throughput experimental studies have indicated that the miRNAome is globally downregulated in various types of malignancy, and dysregulation of miRNAs processing component(s) is one possible mechanism for this phenomenon. Despite the progression in identifying cellular functions of Digeorge Syndrome Critical Region 8 (DGCR8) in miRNAs biogenesis, the role of altered expression of DGCR8 in the pathogenesis of invasive ductal breast carcinoma (IDC) has not yet been fully investigated. The objective of the present study was to evaluate DGCR8 mRNA expression in seventy fresh invasive ductal breast carcinomas and matched adjacent non-neoplastic tissues using quantitative real-time PCR and to assess the value of clinicopathological parameters on its expression. Our findings revealed that DGCR8 mRNA expression is upregulated in more than two-thirds of the cancerous specimens (68.66%) when compared to adjacent non-neoplastic tissue. This difference is statistically significant (P
ISSN:0378-1119
1879-0038
DOI:10.1016/j.gene.2016.01.033