Perfluorocarbon NVX-108 increased cerebral oxygen tension after traumatic brain injury in rats

• Published in: Brain research 2016-03, Vol.1634, p.132-139
• Main Authors: Mullah, Saad H, Saha, Biswajit K, Abutarboush, Rania, Walker, Peter B, Haque, Ashraful, Arnaud, Francoise G, Hazzard, Brittany, Auker, Charles R, McCarron, Richard M, Scultetus, Anke H, Moon-Massat, Paula
• Format: Article
• Language: English
• Subjects: Animals; Blood Pressure - drug effects; Brain Injuries, Traumatic - complications; Brain Injuries, Traumatic - metabolism; Brain interstitial oxygen pressure; Cerebral Cortex - drug effects; Cerebral Cortex - injuries; Cerebral Cortex - metabolism; Early resuscitation; Fluorocarbons - administration & dosage; Heart Rate - drug effects; Hypoxia - etiology; Hypoxia - metabolism; Hypoxia - prevention & control; Male; Neurology; Oxygen therapeutics; Partial Pressure; Perfluorocarbon; Phosphorescence quenching method; Rats; Rats, Sprague-Dawley; Traumatic brain injury
• ISSN: 0006-8993; 1872-6240
• DOI: 10.1016/j.brainres.2016.01.012

Abstract Background Hypoxia is a critical secondary injury mechanism in traumatic brain injury (TBI), and early intervention to alleviate post-TBI hypoxia may be beneficial. NVX-108, a dodecafluoropentane perfluorocarbon, was screened for its ability to increase brain tissue oxygen tension (PbtO2 ) when administered soon after TBI. Methods Ketamine-acepromazine anesthetized rats ventilated with 40% oxygen underwent moderate controlled cortical impact (CCI)-TBI at time 0 (T0). Rats received either no treatment (NON, n =8) or 0.5 ml/kg intravenous (IV) NVX-108 (NVX, n =9) at T15 (15 min after TBI) and T75. Results Baseline cortical PbtO2 was 28±3 mm Hg and CCI-TBI resulted in a 46±6% reduction in PbtO2 at T15 ( P