NMDA and non-NMDA glutamate receptors in the paraventricular nucleus of the hypothalamus modulate different stages of hemorrhage-evoked cardiovascular responses in rats

Highlights • Hemorrhage causes cardiovascular changes. • Cardiac sympathetic activity mediates hemorrhage-induced tachycardiac response. • AVP participates in sympathoinhibitory and recompesatory phases of hemorrhage. • PVN NMDA receptors facilitate the hemorrhage-induced hypotension. • PVN non-NMDA...

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Bibliographic Details
Published in:Neuroscience 2016-04, Vol.320, p.149-159
Main Authors: Busnardo, C, Crestani, C.C, Fassini, A, Resstel, L.B.M, Corrêa, F.M.A
Format: Article
Language:English
Subjects:
Animals
cardiovascular system
Cardiovascular System - physiopathology
Disease Models, Animal
glutamate neurotransmission
Hemodynamics - physiology
Hemorrhage - complications
hemorrhagic shock
Male
Neurology
Paraventricular Hypothalamic Nucleus - metabolism
paraventricular nucleus of hypothalamus
Rats
Rats, Wistar
Receptors, Glutamate - metabolism
sympathetic activity
vasopressin
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Description
Summary:Highlights • Hemorrhage causes cardiovascular changes. • Cardiac sympathetic activity mediates hemorrhage-induced tachycardiac response. • AVP participates in sympathoinhibitory and recompesatory phases of hemorrhage. • PVN NMDA receptors facilitate the hemorrhage-induced hypotension. • PVN non-NMDA glutamate receptors facilitate post-bleeding recovery of MAP.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2016.02.003