Exposure to fipronil elevates systolic blood pressure and disturbs related biomarkers in plasma of rats

Highlights • Pesticide fipronil elevates the blood pressure in rats. • High levels of vasoconstrictor peptide endothelin-1 were induced by fipronil exposure. • Low antioxidant capacity is secondary to fipronil exposure. • Fipronil exposure reduced matrix metalloproteinase 2 and nitric oxide.

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Bibliographic Details
Published in:Environmental toxicology and pharmacology 2016-03, Vol.42, p.63-68
Main Authors: Chaguri, Joao Leandro, Godinho, Antonio Francisco, Horta, Daniel França, Gonçalves-Rizzi, Victor Hugo, Possomato-Vieira, Jose Sergio, Nascimento, Regina Aparecida, Dias-Junior, Carlos Alan
Format: Article
Language:English
Subjects:
Animals
Biomarkers
Biomarkers - blood
Blood Pressure - drug effects
Cardiovascular toxicity
Emergency
Fipronil
Insecticides - toxicity
Male
Matrix Metalloproteinase 2 - blood
Nitric Oxide - blood
Pesticides
Pyrazoles - toxicity
Rats
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Description
Summary:Highlights • Pesticide fipronil elevates the blood pressure in rats. • High levels of vasoconstrictor peptide endothelin-1 were induced by fipronil exposure. • Low antioxidant capacity is secondary to fipronil exposure. • Fipronil exposure reduced matrix metalloproteinase 2 and nitric oxide.
ISSN:1382-6689
1872-7077
DOI:10.1016/j.etap.2015.12.020