Cell biology and immunology lessons taught by Legionella pneumophila

Legionella pneumophila is a facultative intracellular pathogen capable of replicating within a broad range of hosts. One unique feature of this pathogen is the cohort of ca. 300 virulence factors （effectors） delivered into host cells via its Dot/Icm type IV secretion system. Study of these proteins...

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Bibliographic Details
Published in:Science China. Life sciences 2016-01, Vol.59 (1), p.3-10
Main Authors: Zhu, Wenhan, Luo, Zhao-Qing
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Host-Pathogen Interactions - immunology
Humans
Immunity, Innate
Legionella pneumophila
Legionella pneumophila - immunology
Legionella pneumophila - pathogenicity
Legionella pneumophila - physiology
Legionnaires' Disease - immunology
Legionnaires' Disease - microbiology
Life Sciences
Models, Immunological
Review
Type IV Secretion Systems - immunology
Virulence - immunology
免疫学
分泌系统
嗜肺军团菌
宿主细胞
细胞生物学
致病因素
课程
调节机制
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Summary:Legionella pneumophila is a facultative intracellular pathogen capable of replicating within a broad range of hosts. One unique feature of this pathogen is the cohort of ca. 300 virulence factors （effectors） delivered into host cells via its Dot/Icm type IV secretion system. Study of these proteins has produced novel insights into the mechanisms of host function modulation by pathogens, the regulation of essential processes of eukaryotic cells and of immunosurveillance. In this review, we will briefly discuss the roles of some of these effectors in the creation of a niche permissive for bacterial replication in phagocytes and re- cent advancements in the dissection of the innate immune detection mechanisms by challenging immune cells with L. pneu- mophila.
ISSN:1674-7305
1869-1889
DOI:10.1007/s11427-015-4945-x