Role of Circulating Cell-Free DNA in Cancers

Liquid biopsy is a term used to describe non-invasive tests, which provide information about disease conditions through analysis of circulating cell-free DNA and circulating tumor cells from peripheral blood samples. In patients with cancer, the concentration of cell-free DNA increases, and structur...

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Bibliographic Details
Published in:Molecular diagnosis & therapy 2015-12, Vol.19 (6), p.339-350
Main Authors: Aarthy, Raghu, Mani, Samson, Velusami, Sridevi, Sundarsingh, Shirley, Rajkumar, Thangarajan
Format: Article
Language:English
Subjects:
Apoptosis
Biomarkers
Biomedical and Life Sciences
Biomedicine
Biopsy
Breast cancer
Cancer Research
Deoxyribonucleic acid
Disease
DNA
DNA methylation
Gangrene
Gastric cancer
Genes
Heart attacks
Human Genetics
Laboratory Medicine
Medical diagnosis
Medical prognosis
Metastasis
Molecular Medicine
Molecular weight
Patients
Pharmacotherapy
Plasma
Proteins
Review Article
Tumors
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Summary:Liquid biopsy is a term used to describe non-invasive tests, which provide information about disease conditions through analysis of circulating cell-free DNA and circulating tumor cells from peripheral blood samples. In patients with cancer, the concentration of cell-free DNA increases, and structural, sequence, and epigenetic changes to DNA can be observed through the disease process and during therapy. Furthermore, cell-free DNA released by the tumor contains the same variants as those in the tumor cells. Therefore, cell-free DNA allows non-invasive assessment of cancer in real time. This review summarizes the origin of cell-free DNA, recent advancements in the detection of cell-free DNA, a possible role in metastasis, and its importance as a non-invasive diagnostic assay for cancer.
ISSN:1177-1062
1179-2000
DOI:10.1007/s40291-015-0167-y