DNA methylation, histone acetylation and methylation of epigenetic modifications as a therapeutic approach for cancers

Highlights • This review summarizes the roles of epigenetic modification. • Epigenetic modification connects gene regulation, cancer, sugar metabolism, ROS, carcinogenesis, and therapeutic targets. • We discuss the combined treatment of epigenetic regulator and cancer therapy. • We highlight ongoing...

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Bibliographic Details
Published in:Cancer letters 2016-04, Vol.373 (2), p.185-192
Main Authors: Yen, Ching-Yu, Huang, Hurng-Wern, Shu, Chih-Wen, Hou, Ming-Feng, Yuan, Shyng-Shiou F, Wang, Hui-Ru, Chang, Yung-Ting, Farooqi, Ammad Ahmad, Tang, Jen-Yang, Chang, Hsueh-Wei
Format: Article
Language:English
Subjects:
Acetylation
Animals
Autophagy
Breast cancer
Cancer therapies
Carbohydrate Metabolism
Chromatin
DNA Methylation
Epigenesis, Genetic
Epigenetic modification
Glycolysis - drug effects
Hematology, Oncology and Palliative Medicine
Histone
Histones - metabolism
Humans
Methylation
Mutation
Neoplasms - drug therapy
Neoplasms - genetics
Neoplasms - metabolism
Neoplasms - pathology
Oxidative Stress
Sugar metabolism
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Summary:Highlights • This review summarizes the roles of epigenetic modification. • Epigenetic modification connects gene regulation, cancer, sugar metabolism, ROS, carcinogenesis, and therapeutic targets. • We discuss the combined treatment of epigenetic regulator and cancer therapy. • We highlight ongoing efforts in the epigenetic modification field into cancer therapy.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2016.01.036