Characterization of clinical and immunological features in patients coinfected with dengue virus and HIV

Abstract The pathogenesis of dengue in subjects coinfected with HIV remains largely unknown. We investigate clinical and immunological parameters in coinfected DENV/HIV patients. According to the new dengue classification, most coinfected DENV/HIV patients presented mild clinical manifestations of d...

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Bibliographic Details
Published in:Clinical immunology (Orlando, Fla.) Fla.), 2016-03, Vol.164, p.95-105
Main Authors: Torrentes-Carvalho, Amanda, Hottz, Eugênio Damaceno, Marinho, Cintia Ferreira, da Silva, Jéssica Badolato-Corrêa, de Oliveira Pinto, Luzia Maria, Fialho, Luciana Gomes, Bozza, Fernando Augusto, Cunha, Rivaldo Venâncio, Damasco, Paulo Vieira, Kubelka, Claire Fernandes, de Azeredo, Elzinandes Leal
Format: Article
Language:English
Subjects:
Adult
Aged
Allergy and Immunology
CD4-CD8 Ratio
CD8-Positive T-Lymphocytes - immunology
Coinfection
Coinfection - blood
Coinfection - immunology
Cytokines
Cytokines - blood
Dengue
Dengue - blood
Dengue - immunology
Dengue virus
Female
Flaviviridae
HIV
HIV Infections - blood
HIV Infections - immunology
Human immunodeficiency virus
Humans
Lentivirus
Lymphocytes
Male
Middle Aged
Retroviridae
Young Adult
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Summary:Abstract The pathogenesis of dengue in subjects coinfected with HIV remains largely unknown. We investigate clinical and immunological parameters in coinfected DENV/HIV patients. According to the new dengue classification, most coinfected DENV/HIV patients presented mild clinical manifestations of dengue infection. Herein, we show that DENV/HIV coinfected patients had higher CD8 T cells percentages reflected as a lower CD4/CD8 ratio. Furthermore, CCR5 expression on CD4 T cells and CD107a expression on both T subsets were significantly higher in coinfected patients when compared with monoinfected DENV and HIV individuals respectively. Increased inflammatory response was observed in treated HAART coinfected patients despite undetectable HIV load. These data indicate that DENV infection may influence the clinical profile and immune response in individuals concomitantly infected with HIV.
ISSN:1521-6616
1521-7035
DOI:10.1016/j.clim.2016.01.005