Atopic endotype in childhood

Background The term atopic disorder is an early attempt to define specific endotypes of children with asthma, eczema, or both and increased IgE levels. Objective We performed a longitudinal analysis of the relevance of the atopic endotype from birth to age 13 years. Methods Allergic sensitization ag...

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Bibliographic Details
Published in:Journal of allergy and clinical immunology 2016-03, Vol.137 (3), p.844-851.e4
Main Authors: Schoos, Ann-Marie Malby, MD, PhD, Chawes, Bo Lund, MD, PhD, Rasmussen, Morten Arendt, PhD, Bloch, Joakim, MS, Bønnelykke, Klaus, MD, PhD, Bisgaard, Hans, MD, DMSc
Format: Article
Language:English
Subjects:
Adolescent
Age
Age Factors
Algorithms
Allergens - immunology
Allergies
Allergy and Immunology
Asthma
Asthma - diagnosis
Asthma - immunology
Child
Child, Preschool
children
Children & youth
Clinical outcomes
eczema
Eczema - diagnosis
Eczema - immunology
Endotype
Female
Food
Humans
Hypersensitivity, Immediate - diagnosis
Hypersensitivity, Immediate - epidemiology
Hypersensitivity, Immediate - immunology
Immunization
Immunoglobulin E - immunology
Infant
Male
Prevalence
Prospective Studies
sensitization
skin prick test
Skin Tests
Socioeconomic Factors
specific IgE
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Summary:Background The term atopic disorder is an early attempt to define specific endotypes of children with asthma, eczema, or both and increased IgE levels. Objective We performed a longitudinal analysis of the relevance of the atopic endotype from birth to age 13 years. Methods Allergic sensitization against 28 inhalant and food allergens was assessed at ½, 1½, 4, 6, and 13 years of age in 399 children from the Copenhagen Prospective Study on Asthma in Childhood2000 birth cohort by using both skin prick test responses and specific IgE levels. Asthma and eczema were diagnosed longitudinally by strictly adhering to predefined algorithms. Associations between allergic sensitization, asthma, and eczema were estimated by means of logistic regression, and a machine learning approach was used to identify temporal phenotype clusters of these traits. Results Allergic sensitization showed no association with asthma through early childhood (0-6 years) when analyzed as any sensitization (odds ratio [OR] range, 0.78-1.29; P  ≥ .48). However, at 13 years of age, any sensitization was associated with asthma (OR range, 4.02-5.94; all P  
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2015.10.004