A new Gal/GalNAc-specific lectin from the mussel Mytilus trossulus: Structure, tissue specificity, antimicrobial and antifungal activity

In the present study, a new Gal/GalNAc specific lectin from the mussel Mytilus trossulus (designated as MTL) was identified, and its expression levels, both in tissues and toward pathogen stimulation, were then characterized. The MTL primary structure was determined via cDNA sequencing. Deduced sequ...

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Bibliographic Details
Published in:Fish & shellfish immunology 2016-03, Vol.50, p.27-33
Main Authors: Chikalovets, Irina V, Kovalchuk, Svetlana N, Litovchenko, Alina P, Molchanova, Valentina I, Pivkin, Mikhail V, Chernikov, Oleg V
Format: Article
Language:English
Subjects:
Crenomytilus grayanus
Marine
Mytilus galloprovincialis
Mytilus trossulus
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Summary:In the present study, a new Gal/GalNAc specific lectin from the mussel Mytilus trossulus (designated as MTL) was identified, and its expression levels, both in tissues and toward pathogen stimulation, were then characterized. The MTL primary structure was determined via cDNA sequencing. Deduced sequence of 150 amino acid residues showed 89% similarity to lectins from the mussels Crenomytilus grayanus and Mytilus galloprovincialis that were the first members of a new family of zoolectins. The results indicated that the MTL might be involved in immune response toward pathogen infection, and it might perform different recognition specificity toward bacteria or fungi.
ISSN:1050-4648
DOI:10.1016/j.fsi.2016.01.020