Minimum number of trials required for within- and between-session reliability of TMS measures of corticospinal excitability

Highlights • TMS-elicited motor-evoked potentials (MEPs) are highly variable. • We examined the number of trials required for a reliable estimate of MEP amplitude. • ∼20–30 trials were required to ensure reliability both within and between sessions. • Stimulating with more than 30 trials provided no...

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Bibliographic Details
Published in:Neuroscience 2016-04, Vol.320, p.205-209
Main Authors: Goldsworthy, M.R, Hordacre, B, Ridding, M.C
Format: Article
Language:English
Subjects:
Adolescent
Adult
between-session reliability
Electromyography
Evoked Potentials, Motor - physiology
Female
Humans
Male
motor-evoked potential
Neurology
primary motor cortex
Pyramidal Tracts
Reproducibility of Results
transcranial magnetic stimulation
Transcranial Magnetic Stimulation - methods
within-session reliability
Young Adult
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Summary:Highlights • TMS-elicited motor-evoked potentials (MEPs) are highly variable. • We examined the number of trials required for a reliable estimate of MEP amplitude. • ∼20–30 trials were required to ensure reliability both within and between sessions. • Stimulating with more than 30 trials provided no additional benefit. • 30 trials may be optimal for estimating corticospinal excitability using TMS.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2016.02.012