Innovative perspectives of immunotherapy in head and neck cancer. From relevant scientific rationale to effective clinical practice

Highlights • Comprehensive review about role of immune system in HNSCC. • Description of interplay between tumor immune infiltration and HPV status in HNSCC. • Immune escape mechanisms in HNSCC and clinical perspectives for the future.

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Bibliographic Details
Published in:Cancer treatment reviews 2016-02, Vol.43, p.113-123
Main Authors: Lalami, Y, Awada, A
Format: Article
Language:English
Subjects:
Carcinogenesis
Disease Management
Forecasting
Genomic Instability - physiology
Head and neck cancer
Head and Neck Neoplasms - drug therapy
Head and Neck Neoplasms - etiology
Head and Neck Neoplasms - immunology
Hematology, Oncology and Palliative Medicine
HPV
Humans
Immune system
Immunotherapy
Immunotherapy - methods
Immunotherapy - trends
Molecular Targeted Therapy - methods
Molecular Targeted Therapy - trends
Translational Medical Research
Tumor Escape - drug effects
Tumor immune infiltration
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Description
Summary:Highlights • Comprehensive review about role of immune system in HNSCC. • Description of interplay between tumor immune infiltration and HPV status in HNSCC. • Immune escape mechanisms in HNSCC and clinical perspectives for the future.
ISSN:0305-7372
1532-1967
DOI:10.1016/j.ctrv.2016.01.001