Tolerance to Trypanosomatids: A Threat, or a Key for Disease Elimination?

So far, research on trypanosomatid infections has been driven by ‘disease by disease’ approaches, leading to different concepts and control strategies. It is, however, increasingly clear that they share common features such as the ability to generate long-lasting asymptomatic infections in their mam...

Full description

Saved in:
Bibliographic Details
Published in:Trends in parasitology 2016-02, Vol.32 (2), p.157-168
Main Authors: Berthier, David, Brenière, Simone F, Bras-Gonçalves, Rachel, Lemesre, Jean-Loup, Jamonneau, Vincent, Solano, Philippe, Lejon, Veerle, Thévenon, Sophie, Bucheton, Bruno
Format: Article
Language:English
Subjects:
Animals
asymptomatic
Chagas Disease - prevention & control
Disease Eradication
elimination
Gastroenterology and Hepatology
Humans
Immune Tolerance
Infectious Disease
leishmaniasis
Leishmaniasis - prevention & control
Trypanosoma
Trypanosoma - physiology
trypanosomatids
trypanosomiasis
Trypanosomiasis, African - immunology
Trypanosomiasis, African - prevention & control
Trypanotolerance
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:So far, research on trypanosomatid infections has been driven by ‘disease by disease’ approaches, leading to different concepts and control strategies. It is, however, increasingly clear that they share common features such as the ability to generate long-lasting asymptomatic infections in their mammalian hosts. Trypanotolerance, long integrated in animal African trypanosomiasis control, historically refers to the ability of cattle breeds to limit Trypanosoma infection and pathology, but has only recently been recognized in humans. Whilst trypanotolerance is absent from the vocabulary on leishmaniasis and Chagas disease, asymptomatic infections also occur. We review the concept of trypanotolerance across the trypanosomatids and discuss the importance of asymptomatic carriage in the current context of elimination.
ISSN:1471-4922
1471-5007
DOI:10.1016/j.pt.2015.11.001