Antigen Presentation of Vacuolated Apicomplexans – Two Gateways to a Vaccine Antigen

For parasites that sequester themselves within a vacuole, new rules governing antigen presentation are coming into focus. Components of the host's autophagy machinery and the parasite's membranous nanotubular network within the parasitophorous vacuole play a major role in determining antig...

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Bibliographic Details
Published in:Trends in parasitology 2016-02, Vol.32 (2), p.88-90
Main Author: Jensen, Kirk D.C
Format: Article
Language:English
Subjects:
Animals
Antigens - immunology
Apicomplexa - immunology
Autophagy
CD8-Positive T-Lymphocytes - immunology
Gastroenterology and Hepatology
Humans
Infectious Disease
Protozoan Vaccines
Toxoplasma
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Summary:For parasites that sequester themselves within a vacuole, new rules governing antigen presentation are coming into focus. Components of the host's autophagy machinery and the parasite's membranous nanotubular network within the parasitophorous vacuole play a major role in determining antigenicity of Toxoplasma proteins. As such, both parasite and vaccinologist may exploit these pathways to regulate the ever important CD8 T cell response to apicomplexan parasites.
ISSN:1471-4922
1471-5007
DOI:10.1016/j.pt.2015.12.011