Current and future antifungal therapy: new targets for antifungal therapy

Invasive fungal infections will continue to cause major complications in immunocompromized patients. At the moment, the expansion of antifungal drug research has occurred because there is a critical need for new antifungal agents to treat these life-threatening invasive fungal infections. The overvi...

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Bibliographic Details
Published in:International journal of antimicrobial agents 2000-11, Vol.16 (3), p.317-321
Main Author: Andriole, Vincent T
Format: Article
Language:English
Subjects:
Anti fungal compounds
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antifungal agents
Antifungal Agents - pharmacology
Antifungal Agents - therapeutic use
Antifungal targets
Biological and medical sciences
Drug Design
Forecasting
Humans
Immunocompromised Host
Investigational azoles
Investigational polyenes
Medical sciences
Mycoses - drug therapy
Nucleosides - pharmacology
Nucleosides - therapeutic use
Pharmacology. Drug treatments
Polyenes - pharmacology
Polyenes - therapeutic use
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Summary:Invasive fungal infections will continue to cause major complications in immunocompromized patients. At the moment, the expansion of antifungal drug research has occurred because there is a critical need for new antifungal agents to treat these life-threatening invasive fungal infections. The overview of the development of antifungal therapy which is provided here demonstrates the increased interest in this very special area of infectious diseases. Although we now have some newer and less toxic antifungal agents that are currently available for clinical use, their clinical efficacy in some invasive fungal infections, such as aspergillosis and fusariosis, is not very good. Intense efforts in antifungal drug discovery are urgently needed to develop more promising and effective antifungal agents for use in the clinical arena.
ISSN:0924-8579
1872-7913
DOI:10.1016/S0924-8579(00)00258-2