Circadian Dexras1 in rats: Development, location and responsiveness to light

Dexras1 has been shown to exhibit clock-dependent rhythm in mice suprachiasmatic nucleus (SCN), and its genetic deletion modulates circadian responses to photic and nonphotic cues. We show that the rhythmic expression of Dexras1 mRNA and protein in rat SCN already oscillates with low amplitude at po...

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Bibliographic Details
Published in:Chronobiology international 2016-02, Vol.33 (2), p.141-150
Main Authors: Hahnová, Klára, Pačesová, Dominika, Volfová, Barbora, Červená, Kateřina, Kašparová, Dita, Žurmanová, Jitka, Bendová, Zdeňka
Format: Article
Language:English
Subjects:
Animals
Biological Clocks - physiology
Circadian Rhythm - physiology
Female
Light
Male
Period Circadian Proteins - metabolism
Photic Stimulation - methods
ras Proteins - genetics
Rats, Wistar
RNA, Messenger - metabolism
Suprachiasmatic Nucleus - physiology
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Summary:Dexras1 has been shown to exhibit clock-dependent rhythm in mice suprachiasmatic nucleus (SCN), and its genetic deletion modulates circadian responses to photic and nonphotic cues. We show that the rhythmic expression of Dexras1 mRNA and protein in rat SCN already oscillates with low amplitude at postnatal day 3 and can be detected as early as embryonic day 20. In contrast, its expression in peripheral tissues is not rhythmic in adult rats either. The Dexras1 protein is expressed predominantly in the dorsomedial part of the SCN and the light pulse has only a limited effect on its expression. Our data provide the descriptive basis for speculation about the Dexras1 involvement in the rat circadian physiology.
ISSN:0742-0528
1525-6073
DOI:10.3109/07420528.2015.1120741