Stochastic fluctuations in gene expression in aging hippocampal neurons could be exacerbated by traumatic brain injury

Traumatic brain injury (TBI) is a risk factor for age-related dementia and development of neurodegenerative disorders such as Alzheimer’s disease that are associated with cognitive decline. The exact mechanism for this risk is unknown but we hypothesized that TBI is exacerbating age-related changes...

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Bibliographic Details
Published in:Aging clinical and experimental research 2016-04, Vol.28 (2), p.363-367
Main Authors: Shearer, Joseph, Boone, Deborah, Weisz, Harris, Jennings, Kristofer, Uchida, Tatsuo, Parsley, Margaret, DeWitt, Douglas, Prough, Donald, Hellmich, Helen
Format: Article
Language:English
Subjects:
Age
Aging
Aging - genetics
Aging - psychology
Animals
Brain Injuries, Traumatic - complications
Brain Injuries, Traumatic - psychology
Cell Death - physiology
Cell Survival - physiology
Cognition Disorders - etiology
Cognition Disorders - physiopathology
Disease Models, Animal
Gene expression
Gene Expression Profiling - statistics & numerical data
Geriatrics/Gerontology
Hippocampus - pathology
Laser Capture Microdissection - methods
Medicine
Medicine & Public Health
Neurons - pathology
Rats
Short Communication
Stochastic Processes
Traumatic brain injury
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Summary:Traumatic brain injury (TBI) is a risk factor for age-related dementia and development of neurodegenerative disorders such as Alzheimer’s disease that are associated with cognitive decline. The exact mechanism for this risk is unknown but we hypothesized that TBI is exacerbating age-related changes in gene expression. Here, we present evidence in an animal model that experimental TBI increases age-related stochastic gene expression. We compared the variability in expression of several genes associated with cell survival or death, among three groups of laser capture microdissected hippocampal neurons from aging rat brains. TBI increased stochastic fluctuations in gene expression in both dying and surviving neurons compared to the naïve neurons. Increases in random, stochastic fluctuations in prosurvival or prodeath gene expression could potentially alter cell survival or cell death pathways in aging neurons after TBI which may lead to age-related cognitive decline.
ISSN:1720-8319
1594-0667
1720-8319
DOI:10.1007/s40520-015-0396-2