Pathology and Surgical Treatment of High-Grade Pancreatic Neuroendocrine Carcinoma: an Evolving Landscape

Pancreatic neuroendocrine neoplasms (PNENs) are rare, accounting for less than 5 % of all pancreatic tumors. High-grade pancreatic neuroendocrine carcinomas (hgPNECs) represent about 5 % of all PNENs. They show highly aggressive behavior with dismal prognosis. Throughout the last two decades, there...

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Bibliographic Details
Published in:Current oncology reports 2016-05, Vol.18 (5), p.28-28, Article 28
Main Authors: Haugvik, Sven-Petter, Kaemmerer, Daniel, Gaujoux, Sebastien, Labori, Knut Jørgen, Verbeke, Caroline Sophie, Gladhaug, Ivar Prydz
Format: Article
Language:English
Subjects:
Biomarkers, Tumor - analysis
Carcinoma, Neuroendocrine - metabolism
Carcinoma, Neuroendocrine - pathology
Carcinoma, Neuroendocrine - surgery
Gastrointestinal Cancers (J Meyer
Humans
Ki-67 Antigen - analysis
Medicine
Medicine & Public Health
Mitotic Index
Neoplasm Grading
Oncology
Pancreatic Neoplasms - metabolism
Pancreatic Neoplasms - pathology
Pancreatic Neoplasms - surgery
Prognosis
Section Editor
Survival Analysis
Topical Collection on Gastrointestinal Cancers
Treatment Outcome
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Summary:Pancreatic neuroendocrine neoplasms (PNENs) are rare, accounting for less than 5 % of all pancreatic tumors. High-grade pancreatic neuroendocrine carcinomas (hgPNECs) represent about 5 % of all PNENs. They show highly aggressive behavior with dismal prognosis. Throughout the last two decades, there has been a notable progress in basic and clinical research of PNENs and a therapeutic trend towards both more aggressive and minimally invasive surgery. Despite these advances, hgPNECs as a distinct clinical entity remains largely unexplored among surgeons. This review of current development in pathology reporting and surgical treatment of hgPNECs aims at increasing the awareness of an evolving field in pancreatic surgery.
ISSN:1523-3790
1534-6269
DOI:10.1007/s11912-016-0518-9