Apathy, ventriculomegaly and neurocognitive improvement following shunt surgery in normal pressure hydrocephalus

Introduction. Apathy - impaired motivation and goal-directed behaviour - is a common yet often overlooked symptom in normal pressure hydrocephalus (NPH). Caudate atrophy often yields apathetic symptoms; however, this structural and functional relationship has not yet been explored in NPH. Additional...

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Bibliographic Details
Published in:British journal of neurosurgery 2016-01, Vol.30 (1), p.38-42
Main Authors: Peterson, Katie A., Housden, Charlotte R., Killikelly, Clare, DeVito, Elise E., Keong, Nicole C., Savulich, George, Czosnyka, Zofia, Pickard, John D., Sahakian, Barbara J.
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Apathy
Apathy - physiology
audit
caudate nucleus
Cognition & reasoning
Cognition - physiology
cognitive function
Correlation analysis
Depression - physiopathology
Female
Humans
Hydrocephalus, Normal Pressure - surgery
Male
Mental depression
Middle Aged
Neuropsychological Tests
normal pressure hydrocephalus
Treatment Outcome
Ventriculoperitoneal Shunt - adverse effects
Ventriculoperitoneal Shunt - methods
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Summary:Introduction. Apathy - impaired motivation and goal-directed behaviour - is a common yet often overlooked symptom in normal pressure hydrocephalus (NPH). Caudate atrophy often yields apathetic symptoms; however, this structural and functional relationship has not yet been explored in NPH. Additionally, little is known about the relationship between apathy and post-shunt cognitive recovery. Methods. This audit investigated whether apathetic symptoms improve following shunt surgery in NPH, and whether this relates to cognitive response. In addition, we assessed the relationship between ventriculomegaly and apathy using the bicaudate ratio. Twenty-two patients with NPH completed the Mini-Mental State Examination (MMSE), the Apathy Evaluation Scale (AES) and the Geriatric Depression Scale (GDS) before and 3-9 months after shunt surgery. Pre-operative ventriculomegaly was correlated with pre-operative AES and GDS scores. Difference scores (post-shunt minus baseline values) for AES and GDS were correlated with cognitive outcome. Results. Greater pre-operative ventriculomegaly was associated with increased level of apathy and depression. A reduction in apathetic symptoms following shunt surgery was associated with improved performance on the MMSE. Conclusions. Apathy may be indicative of a greater degree of subcortical atrophy in NPH and may relate to functional outcome.
ISSN:0268-8697
1360-046X
DOI:10.3109/02688697.2015.1029429