Recurrent Stroke with Rapid Development of Intracranial Stenoses in Polycythemia Vera

Polycythemia vera (PV) is a blood disorder in which the first expression may be an ischemic stroke. Stroke mechanism in PV is usually attributed to a hypercoagulability state and blood stasis. We report a case of a patient with PV presenting with recurrent ischemic stroke associated with the develop...

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Bibliographic Details
Published in:Journal of stroke and cerebrovascular diseases 2016-04, Vol.25 (4), p.e41-e43
Main Authors: Crespo, Ane M., MD, Abraira, Laura, MD, Guanyabens, Nicolau, MD, Millán, Mónica, MD, PhD, Munuera, Josep, MD, Dávalos, Antoni, MD, PhD, López-Cancio, Elena, MD, PhD
Format: Article
Language:English
Subjects:
Cardiovascular
Constriction, Pathologic - diagnostic imaging
Constriction, Pathologic - etiology
Humans
intracranial stenosis
Magnetic Resonance Angiography
Magnetic Resonance Imaging
Male
microembolic signals
Middle Aged
Neurology
polycythemia vera
Polycythemia Vera - complications
Polycythemia Vera - diagnostic imaging
Stroke
Stroke - diagnostic imaging
Stroke - etiology
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Summary:Polycythemia vera (PV) is a blood disorder in which the first expression may be an ischemic stroke. Stroke mechanism in PV is usually attributed to a hypercoagulability state and blood stasis. We report a case of a patient with PV presenting with recurrent ischemic stroke associated with the development of large intracranial stenosis in a period of 1 month. Stenosis was associated with microembolic signals detected by transcranial Doppler. One year later and after hematocrit control, stenosis persisted but microembolic signals disappeared. We discuss similar reports in the literature and the possible pathophysiological mechanism of large-vessel damage in these patients.
ISSN:1052-3057
1532-8511
DOI:10.1016/j.jstrokecerebrovasdis.2015.12.030