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Recurrent Stroke with Rapid Development of Intracranial Stenoses in Polycythemia Vera
Polycythemia vera (PV) is a blood disorder in which the first expression may be an ischemic stroke. Stroke mechanism in PV is usually attributed to a hypercoagulability state and blood stasis. We report a case of a patient with PV presenting with recurrent ischemic stroke associated with the develop...
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| Published in: | Journal of stroke and cerebrovascular diseases 2016-04, Vol.25 (4), p.e41-e43 |
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| Main Authors: | , , , , , , |
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| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c459t-3f764d5b1d724d9fe1ed479c4a128adbe09451e54d935eb70b019eae3c4a417e3 |
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| cites | cdi_FETCH-LOGICAL-c459t-3f764d5b1d724d9fe1ed479c4a128adbe09451e54d935eb70b019eae3c4a417e3 |
| container_end_page | e43 |
| container_issue | 4 |
| container_start_page | e41 |
| container_title | Journal of stroke and cerebrovascular diseases |
| container_volume | 25 |
| creator | Crespo, Ane M., MD Abraira, Laura, MD Guanyabens, Nicolau, MD Millán, Mónica, MD, PhD Munuera, Josep, MD Dávalos, Antoni, MD, PhD López-Cancio, Elena, MD, PhD |
| description | Polycythemia vera (PV) is a blood disorder in which the first expression may be an ischemic stroke. Stroke mechanism in PV is usually attributed to a hypercoagulability state and blood stasis. We report a case of a patient with PV presenting with recurrent ischemic stroke associated with the development of large intracranial stenosis in a period of 1 month. Stenosis was associated with microembolic signals detected by transcranial Doppler. One year later and after hematocrit control, stenosis persisted but microembolic signals disappeared. We discuss similar reports in the literature and the possible pathophysiological mechanism of large-vessel damage in these patients. |
| doi_str_mv | 10.1016/j.jstrokecerebrovasdis.2015.12.030 |
| format | article |
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Stroke mechanism in PV is usually attributed to a hypercoagulability state and blood stasis. We report a case of a patient with PV presenting with recurrent ischemic stroke associated with the development of large intracranial stenosis in a period of 1 month. Stenosis was associated with microembolic signals detected by transcranial Doppler. One year later and after hematocrit control, stenosis persisted but microembolic signals disappeared. 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We discuss similar reports in the literature and the possible pathophysiological mechanism of large-vessel damage in these patients.</description><subject>Cardiovascular</subject><subject>Constriction, Pathologic - diagnostic imaging</subject><subject>Constriction, Pathologic - etiology</subject><subject>Humans</subject><subject>intracranial stenosis</subject><subject>Magnetic Resonance Angiography</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>microembolic signals</subject><subject>Middle Aged</subject><subject>Neurology</subject><subject>polycythemia vera</subject><subject>Polycythemia Vera - complications</subject><subject>Polycythemia Vera - diagnostic imaging</subject><subject>Stroke</subject><subject>Stroke - diagnostic imaging</subject><subject>Stroke - etiology</subject><issn>1052-3057</issn><issn>1532-8511</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNqVkU1v1DAQhiNERT_gL6AcEVKCxx_rzQUJCpRKKxW1lKvl2BPVaWIvdrJo_z0OW3qouHCakebxO_IzRfEWSA0EVu_6uk9TDPdoMGIbw04n61JNCYgaaE0YeVacgGC0WguA57knglaMCHlcnKbUEwIg1uJFcUxXayoYb06K22s0c4zop_LmT3b5y0135bXeOlt-wh0OYTsu09CVl36K2kTtnR4yjT4kTKXz5bcw7M1-usPR6fIHRv2yOOr0kPDVQz0rbr98_n7-tdpcXVyef9hUhotmqlgnV9yKFqyk3DYdAlouG8M10LW2LZKGC0CRZ0xgK0lLoEGNLBMcJLKz4s0hdxvDzxnTpEaXDA6D9hjmpEBKnn2QZpXRjwfUxJBSxE5toxt13CsgatGrevUvvWrRq4CqrDeHvH7YN7cj2seIvz4zsDkAmH-9cxhVMg69QesimknZ4P5v3_sncWZw3hk93OMeUx_m6LNfBSrlB-pmOfhybxCESOCc_QZbUrAn</recordid><startdate>20160401</startdate><enddate>20160401</enddate><creator>Crespo, Ane M., MD</creator><creator>Abraira, Laura, MD</creator><creator>Guanyabens, Nicolau, MD</creator><creator>Millán, Mónica, MD, PhD</creator><creator>Munuera, Josep, MD</creator><creator>Dávalos, Antoni, MD, PhD</creator><creator>López-Cancio, Elena, MD, PhD</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20160401</creationdate><title>Recurrent Stroke with Rapid Development of Intracranial Stenoses in Polycythemia Vera</title><author>Crespo, Ane M., MD ; Abraira, Laura, MD ; Guanyabens, Nicolau, MD ; Millán, Mónica, MD, PhD ; Munuera, Josep, MD ; Dávalos, Antoni, MD, PhD ; López-Cancio, Elena, MD, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c459t-3f764d5b1d724d9fe1ed479c4a128adbe09451e54d935eb70b019eae3c4a417e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Cardiovascular</topic><topic>Constriction, Pathologic - diagnostic imaging</topic><topic>Constriction, Pathologic - etiology</topic><topic>Humans</topic><topic>intracranial stenosis</topic><topic>Magnetic Resonance Angiography</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>microembolic signals</topic><topic>Middle Aged</topic><topic>Neurology</topic><topic>polycythemia vera</topic><topic>Polycythemia Vera - complications</topic><topic>Polycythemia Vera - diagnostic imaging</topic><topic>Stroke</topic><topic>Stroke - diagnostic imaging</topic><topic>Stroke - etiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Crespo, Ane M., MD</creatorcontrib><creatorcontrib>Abraira, Laura, MD</creatorcontrib><creatorcontrib>Guanyabens, Nicolau, MD</creatorcontrib><creatorcontrib>Millán, Mónica, MD, PhD</creatorcontrib><creatorcontrib>Munuera, Josep, MD</creatorcontrib><creatorcontrib>Dávalos, Antoni, MD, PhD</creatorcontrib><creatorcontrib>López-Cancio, Elena, MD, PhD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of stroke and cerebrovascular diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Crespo, Ane M., MD</au><au>Abraira, Laura, MD</au><au>Guanyabens, Nicolau, MD</au><au>Millán, Mónica, MD, PhD</au><au>Munuera, Josep, MD</au><au>Dávalos, Antoni, MD, PhD</au><au>López-Cancio, Elena, MD, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Recurrent Stroke with Rapid Development of Intracranial Stenoses in Polycythemia Vera</atitle><jtitle>Journal of stroke and cerebrovascular diseases</jtitle><addtitle>J Stroke Cerebrovasc Dis</addtitle><date>2016-04-01</date><risdate>2016</risdate><volume>25</volume><issue>4</issue><spage>e41</spage><epage>e43</epage><pages>e41-e43</pages><issn>1052-3057</issn><eissn>1532-8511</eissn><abstract>Polycythemia vera (PV) is a blood disorder in which the first expression may be an ischemic stroke. Stroke mechanism in PV is usually attributed to a hypercoagulability state and blood stasis. We report a case of a patient with PV presenting with recurrent ischemic stroke associated with the development of large intracranial stenosis in a period of 1 month. Stenosis was associated with microembolic signals detected by transcranial Doppler. One year later and after hematocrit control, stenosis persisted but microembolic signals disappeared. We discuss similar reports in the literature and the possible pathophysiological mechanism of large-vessel damage in these patients.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>26825349</pmid><doi>10.1016/j.jstrokecerebrovasdis.2015.12.030</doi></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1052-3057 |
| ispartof | Journal of stroke and cerebrovascular diseases, 2016-04, Vol.25 (4), p.e41-e43 |
| issn | 1052-3057 1532-8511 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1774532096 |
| source | ScienceDirect Journals |
| subjects | Cardiovascular Constriction, Pathologic - diagnostic imaging Constriction, Pathologic - etiology Humans intracranial stenosis Magnetic Resonance Angiography Magnetic Resonance Imaging Male microembolic signals Middle Aged Neurology polycythemia vera Polycythemia Vera - complications Polycythemia Vera - diagnostic imaging Stroke Stroke - diagnostic imaging Stroke - etiology |
| title | Recurrent Stroke with Rapid Development of Intracranial Stenoses in Polycythemia Vera |
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