Placental ADAMTS-12 Levels in the Pathogenesis of Preeclampsia and Intrahepatic Cholestasis of Pregnancy

Our aim was to determine whether placental A Disintegrin-like Metalloproteinase with ThromboSpondin motif 12 (ADAMTS-12), arylesterase (ARES) levels, total oxidant status (TOS), and total antioxidant status (TAS) differ in preeclampsia, intrahepatic cholestasis of pregnancy (ICP), and uncomplicated...

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Published in:Reproductive sciences (Thousand Oaks, Calif.) Calif.), 2016-04, Vol.23 (4), p.475-481
Main Authors: Oztas, Efser, Ozler, Sibel, Ersoy, Ali O., Erkenekli, Kudret, Sucak, Ayhan, Ergin, Merve, Uygur, Dilek, Danisman, Nuri
Format: Article
Language:English
Subjects:
ADAMTS Proteins - metabolism
Adult
Case-Control Studies
Cholestasis, Intrahepatic - diagnosis
Cholestasis, Intrahepatic - metabolism
Embryology
Female
Humans
Medicine & Public Health
Obstetrics/Perinatology/Midwifery
Original Article
Placenta - metabolism
Placenta - pathology
Pre-Eclampsia - diagnosis
Pre-Eclampsia - metabolism
Pregnancy
Pregnancy Complications - diagnosis
Pregnancy Complications - metabolism
Prospective Studies
Reproductive Medicine
Young Adult
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Summary:Our aim was to determine whether placental A Disintegrin-like Metalloproteinase with ThromboSpondin motif 12 (ADAMTS-12), arylesterase (ARES) levels, total oxidant status (TOS), and total antioxidant status (TAS) differ in preeclampsia, intrahepatic cholestasis of pregnancy (ICP), and uncomplicated pregnancies or not. A prospective case–control study was carried out including 84 pregnant women (26 with ICP, 28 preeclamptic patients, and 30 healthy controls). Levels of ADAMTS-12, TAS, TOS, and ARES were studied in the supernatants of placental tissue homogenates. Placental ADAMTS-12 levels were distributed as 240.9 pg/mg in ICP, 289.7 pg/mg in preeclampsia, and 310.8 pg/mg in control groups. Levels of ADAMTS-12 (odds ratio = 6.509, 95% confidence interval:1.070-39.592, P = .042) in the placenta of the ICP were significantly lower than those in preeclampsia and control groups (P = .004), but no statistical significant difference was determined between preeclampsia and control groups. Decreased levels of placental ADAMTS-12 were found to be associated with ICP, suggesting a possible role of inflammation in the pathogenesis.
ISSN:1933-7191
1933-7205
DOI:10.1177/1933719115604730