Thyroid function for infertile women during ovarian hyperstimulation as part of IVF

• Published in: Gynécologie, obstétrique & fertilité obstétrique & fertilité, 2016-03, Vol.44 (3), p.156-162
• Main Authors: Alnot-Burette, J, Nakib, I, Lipere, A, Delemer, B, Graesslin, O
• Format: Article
• Language: fre
• Subjects: Adult; Female; Fertilization in Vitro; Humans; Infertility, Female - therapy; Ovulation Induction; Pregnancy; Thyroid Diseases - complications; Thyroid Diseases - physiopathology; Thyroid Gland - physiopathology; Thyrotropin - blood; Treatment Outcome
• ISSN: 1769-6682
• DOI: 10.1016/j.gyobfe.2016.01.007

Optimal thyroid function is necessary for an effective fertility. Many authors have suggested that thyroid function has an impact on IVF outcome. Conversely, IVF has been suggested to induce changes in thyroid function. The aim of this study was to determine the nature and the timing of alterations in thyroid function, throughout controlled ovarian hyperstimulation, from the beginning of therapy to the day of triggering ovulation. And make a clarification of the current recommendations of the thyroid function during hormonal stimulation. Subjects were recruited from March 2013 to July 2013 at the Hospital of the University of Reims. The studied population consisted of 50 infertile patients who had undergone IVF/ICSI cycles. Thyroid axis exploration was realized before therapy and at every hormonal dosage during ovarian monitorage. Prematuary fluctuations were observed without impact on pregnancy rate. We could detect potential hypothyroid women thanks to this dosage and define a connection between pregnancy rate and TSH with a threshold closer to 1mUI/L than 2,5mUI/L defined by the endocrine society. The link between thyroid function, forecast of conception and pregnancy is well documented. Currently, there is no recommendation on the rate of TSH targets for the patients in medical assisted procreation.