The correlation between symptoms of definite Meniere's disease and endolymphatic hydrops visualized by magnetic resonance imaging

• Published in: The Laryngoscope 2016-04, Vol.126 (4), p.974-979
• Main Authors: Wu, Qianru, Dai, Chunfu, Zhao, Menglong, Sha, Yan
• Format: Article
• Language: English
• Subjects: Adult; Aged; Contrast Media; Ears & hearing; endolymphatic hydrops; Endolymphatic Hydrops - pathology; Female; Gadolinium; Humans; Imaging, Three-Dimensional; magnetic resonance imaging; Magnetic Resonance Imaging - methods; Male; Meniere disease; Meniere Disease - pathology; Meniere's disease; Middle Aged; NMR; Nuclear magnetic resonance; Prospective Studies; symptom; Tinnitus; Tinnitus - pathology
• ISSN: 0023-852X; 1531-4995
• DOI: 10.1002/lary.25576

Objective/Hypothesis This study aimed at investigating the correlation between a battery of diagnostic symptoms of definite Meniere's disease (MD) and the degree of endolymphatic hydrops (EH) in the inner ear. Study Design Prospective study. Methods Fifty‐four patients diagnosed with unilateral definite MD were enrolled in the study. The hearing levels of all patients at the low, middle, and high frequencies were evaluated. Three‐dimensional fluid‐attenuated inversion recovery (3D‐FLAIR) and three‐dimensional real inversion recovery (3D‐real IR) magnetic resonance imaging (MRI) were performed 24 hours after bilateral intratympanic injection of gadolinium to assess the presence and grading of EH. Results Various degrees of EH were observed in the vestibule and/or each turn of the cochlea in the affected ears of all patients. The duration of MD disease and low‐tone and middle‐tone hearing thresholds were proportional to the extent of EH in the vestibule and cochlear. However, no significant correlation was demonstrated between EH and other aspects of symptoms such as high‐tone hearing loss, tinnitus, and aural fullness. Of all subjects, 16.7% exhibited bilateral EH on MRI exam who were diagnosed with unilateral MD based on diagnostic criteria. Conclusions EH in the inner ear of MD patients exhibits a progressive deteriorative trend over time. Low‐tone and middle‐tone hearing thresholds can indirectly reflect the severity of EH in the cochlea. EH may not be the primary cause of tinnitus and aural fullness in patients with MD. Patients diagnosed with unilateral MD should maintain long‐term regular follow‐ups for the possibility of developing bilateral EH. Level of Evidence 4 Laryngoscope, 126:974–979, 2016