Quantitative agreement between [15O]H2O PET and model free QUASAR MRI-derived cerebral blood flow and arterial blood volume

The purpose of this study was to assess whether there was an agreement between quantitative cerebral blood flow (CBF) and arterial cerebral blood volume (CBVA) measurements by [15O]H2O positron emission tomography (PET) and model‐free QUASAR MRI. Twelve healthy subjects were scanned within a week in...

Full description

Saved in:
Bibliographic Details
Published in:NMR in biomedicine 2016-04, Vol.29 (4), p.519-526
Main Authors: Heijtel, D.F.R., Petersen, E.T., Mutsaerts, H.J.M.M., Bakker, E., Schober, P., Stevens, M.F., van Berckel, B.N.M, Majoie, C.B.L.M., Booij, J., van Osch, M.J.P., van Bavel, E.T., Boellaard, R., Lammertsma, A.A., Nederveen, A.J.
Format: Article
Language:English
Subjects:
Adult
arterial blood volume
Arteries - physiology
ASL
Blood Volume - physiology
cerebral blood flow
Cerebrovascular Circulation - physiology
Female
Hemodynamics
Humans
Magnetic Resonance Imaging - methods
Male
Oxygen Isotopes
PET
Positron-Emission Tomography - methods
quasar
Water - metabolism
Young Adult
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The purpose of this study was to assess whether there was an agreement between quantitative cerebral blood flow (CBF) and arterial cerebral blood volume (CBVA) measurements by [15O]H2O positron emission tomography (PET) and model‐free QUASAR MRI. Twelve healthy subjects were scanned within a week in separate MRI and PET imaging sessions, after which quantitative and qualitative agreement between both modalities was assessed for gray matter, white matter and whole brain region of interests (ROI). The correlation between CBF measurements obtained with both modalities was moderate to high (r2: 0.28–0.60, P 
ISSN:0952-3480
1099-1492
DOI:10.1002/nbm.3480