Supramolecular nanoscale assemblies for cancer diagnosis and therapy

Nanocarriers based on polymers, metals and lipids have been extensively developed for cancer therapy and diagnosis due to their ability to enhance drug accumulation in cancer cells and decrease undesired drug toxicity in healthy tissues. Overcoming multidrug resistance by designing proper drug nanoc...

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Bibliographic Details
Published in:Journal of controlled release 2015-09, Vol.213, p.152-167
Main Authors: Coelho, Sílvia Castro, Pereira, Maria Carmo, Juzeniene, Asta, Juzenas, Petras, Coelho, Manuel A.N.
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents - administration & dosage
Antineoplastic Agents - therapeutic use
Chemotherapy
Drug Carriers - chemistry
Drug delivery systems
Drug Delivery Systems - methods
Gold nanoparticles
Humans
Internalization
Metals - chemistry
Nanoparticles - chemistry
Nanotechnology - methods
Neoplasms - diagnosis
Neoplasms - drug therapy
Polymeric nanoparticles
Polymers - chemistry
Polysaccharides - chemistry
Radiotherapy
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Summary:Nanocarriers based on polymers, metals and lipids have been extensively developed for cancer therapy and diagnosis due to their ability to enhance drug accumulation in cancer cells and decrease undesired drug toxicity in healthy tissues. Overcoming multidrug resistance by designing proper drug nanocarriers will improve outcome of existing oncologic treatments such as chemotherapy and radiotherapy. In this article the relation between physicochemical properties and capacity of a nanosystem to deliver therapeutic agents into pathological sites is discussed. Most promising examples of drug delivery systems are reviewed, and, in particular, the design of a carbohydrate based matrix with entrapped gold nanoparticles is highlighted. [Display omitted]
ISSN:0168-3659
1873-4995
DOI:10.1016/j.jconrel.2015.06.034