Rhabdomyosarcoma in children in the light of isotope ratio mass spectrometry

Rhabdomyosarcoma is the third most common solid tumor in children and the most common soft tissue sarcoma in this age group. However, 5-year survival is only observed in approximately 70% of cases, and the prognosis for patients with progressive disease is still poor. The authors hypothesize that th...

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Bibliographic Details
Published in:Polish journal of pathology 2015-12, Vol.66 (4), p.383-388
Main Authors: Taran, Katarzyna, Frączek, Tomasz, Sitkiewicz, Anna, Paneth, Piotr, Kobos, Józef
Format: Article
Language:English
Subjects:
Age
Cancer
Carbon
Carbon Isotopes - analysis
Chemical elements
Child
Child, Preschool
Chromosomes
Female
Humans
Isotopes
Male
Mass Spectrometry
Medical prognosis
Nitrogen
Nitrogen Isotopes - analysis
Rhabdomyosarcoma - chemistry
Rhabdomyosarcoma - classification
Rhabdomyosarcoma - diagnosis
Scientific imaging
Sulfur
Tumors
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Description
Summary:Rhabdomyosarcoma is the third most common solid tumor in children and the most common soft tissue sarcoma in this age group. However, 5-year survival is only observed in approximately 70% of cases, and the prognosis for patients with progressive disease is still poor. The authors hypothesize that the still unidentified differences in embryonal and alveolar tumor biology reflect the complex chemical reactions occurring during cell growth and metabolism and may be pursued in isotopic fractionation processes. Presented herein is the first evaluation of the nitrogen and carbon isotope ratio using isotope ratio mass spectrometry in the two major rhabdomyosarcoma histologic types. 15N enrichment was found in tumor tissues of embryonal histological type. The obtained result may indicate that individual patient considerations such as isotope ratio, in addition to widely accepted prognostic factors, may facilitate patient classification in terms of risk groups.
ISSN:1233-9687
2084-9869
DOI:10.5114/PJP.2015.57251