Two Autoimmune Diabetes Loci Influencing T Cell Apoptosis Control Susceptibility to Experimental Autoimmune Myocarditis

The pathogenesis of immune-mediated myocarditis depends on genetic and environmental factors. To study the genetic mechanisms, we have developed a model of experimental autoimmune myocarditis in the A.SW mouse. Here we provide evidence that loci on murine chromosome 6, and possibly chromosome 1, are...

Full description

Saved in:
Bibliographic Details
Published in:The Journal of immunology (1950) 2005-02, Vol.174 (4), p.2167-2173
Main Authors: Guler, Mehmet L, Ligons, Davinna L, Wang, Yan, Bianco, Michael, Broman, Karl W, Rose, Noel R
Format: Article
Language:English
Subjects:
Animals
Apoptosis - drug effects
Apoptosis - genetics
Apoptosis - immunology
Chromosome Mapping
Crosses, Genetic
Cyclophosphamide - pharmacology
Dexamethasone - pharmacology
Diabetes Mellitus, Type 1 - genetics
Diabetes Mellitus, Type 1 - immunology
Diabetes Mellitus, Type 1 - pathology
Disease Models, Animal
Female
Genetic Linkage
Genetic Markers
Genetic Predisposition to Disease - genetics
Immunity, Innate - genetics
Male
Mice
Mice, Inbred A
Mice, Inbred C57BL
Mice, Inbred NOD
Myocarditis - genetics
Myocarditis - immunology
Myocarditis - pathology
Quantitative Trait, Heritable
T-Lymphocytes - drug effects
T-Lymphocytes - pathology
Thymus Gland - cytology
Thymus Gland - drug effects
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The pathogenesis of immune-mediated myocarditis depends on genetic and environmental factors. To study the genetic mechanisms, we have developed a model of experimental autoimmune myocarditis in the A.SW mouse. Here we provide evidence that loci on murine chromosome 6, and possibly chromosome 1, are involved in regulating susceptibility. Moreover, these loci overlap with loci implicated in other autoimmune diseases including diabetes in the NOD mouse. These two loci also regulate apoptosis in thymocytes as well as peripheral T cells in the NOD mouse, and we report further that A.SW mice demonstrate the same characteristics in apoptosis. These results suggest that common pathogenetic mechanisms involving apoptosis of both thymic and peripheral T cells are shared by multiple autoimmune diseases.
ISSN:0022-1767
1550-6606
DOI:10.4049/jimmunol.174.4.2167