Validation of coronary computed tomography angiography scores for non-invasive assessment of atherosclerotic burden through a comparison with multivessel intravascular ultrasound

Abstract Aims While the atherosclerotic plaque volume can be manually quantified in coronary computed tomography angiography (CTA) it is impractical for clinical routine use. Several anatomical scores have been developed as surrogates for overall atherosclerotic burden in coronary CTA and even prove...

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Bibliographic Details
Published in:Atherosclerosis 2016-04, Vol.247, p.21-27
Main Authors: Cavalcante, Rafael, Bittencourt, Marcio S, Pinheiro, Thais L, Falcao, Breno A.A, Morais, Gustavo R, Soares, Paulo, Mariani, José, Ribeiro, Expedito, Kalil-Filho, Roberto, Rochitte, Carlos E, Lemos, Pedro A
Format: Article
Language:English
Subjects:
Aged
Area Under Curve
Atherosclerosis
Cardiovascular
Computed tomography
Computed Tomography Angiography
Coronary Angiography - methods
Coronary Artery Disease - diagnostic imaging
Coronary disease
Coronary Vessels - diagnostic imaging
Female
Humans
Intravascular ultrasound
Male
Middle Aged
Plaque, Atherosclerotic
Predictive Value of Tests
Prospective Studies
Reproducibility of Results
ROC Curve
Severity of Illness Index
Ultrasonography, Interventional
Vascular Calcification - diagnostic imaging
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Summary:Abstract Aims While the atherosclerotic plaque volume can be manually quantified in coronary computed tomography angiography (CTA) it is impractical for clinical routine use. Several anatomical scores have been developed as surrogates for overall atherosclerotic burden in coronary CTA and even proven to be highly predictive for future adverse events. However, they have not been validated against the gold standard for atherosclerotic burden, intra-vascular ultrasound (IVUS). In the present study we have compared several coronary CTA scores with the coronary IVUS. Methods and results A total of 62 patients with diagnosed coronary disease scheduled for percutaneous intervention were prospectively enrolled. For all patients, coronary CTA and multivessel IVUS were obtained. Calcium score and 6 previously reported scores were calculated from coronary CTA imaging and compared to average IVUS-derived percent atheroma volume (PAV). On average, 3.8 ± 0.7 vessels, comprising 123.8 ± 31.3 mm in length, were imaged with IVUS per patient. All but one previously described scoring systems showed a significant association with IVUS-derived PAV. Among them, the SSS score demonstrated the strongest correlation with IVUS-PAV (r = 0.61, p 
ISSN:0021-9150
1879-1484
DOI:10.1016/j.atherosclerosis.2016.01.040